Soonchunhyang Med Sci.  2018 Jun;24(1):1-7. 10.0000/sms.2018.24.1.1.

A Concomitant Hemato-Oncologic Disorder of Patient with Down Syndrome

• Park KB
• Lee DH

• KMID: 2437759
• DOI: http://doi.org/10.0000/sms.2018.24.1.1

Abstract

A patient with Down syndrome has hematologic and oncologic disorders of medical complication. Down syndrome shows that characteristic hematologic and oncologic abnormalities and developments of disorders are different at ages. Many hematologic disorders were related to Down syndrome. There are diseases of red blood cells, white blood cell disorders, platelet and bleeding disorders, aplastic anemia, and transient myeloproliferative disease. Acute myeloid leukemia, acute lymphoblastic leukemia, and rarely solid tumors (Neuroblastoma, Wilm's tumor, Hodgkin's lymphoma) are also associated with Down syndrome. We checked clinical manifestations of each disorder and we should make standard hematologic index of different age groups. In addition, the relations between chromosome 21 and hemato-oncologic disorders should be found. We need to investigate potential therapeutic interventions that can improve quality of life and life expectancy in patients with Down syndrome.

Keyword

Down syndrome; Lymphoblastic leukemia; Acute myeloid leukemia; Myeloproliferative disorders

MeSH Terms

Anemia, Aplastic
Blood Platelets
Chromosomes, Human, Pair 21
Down Syndrome*
Erythrocytes
Hemorrhage
Humans
Leukemia, Myeloid, Acute
Leukocytes
Life Expectancy
Myeloproliferative Disorders
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Quality of Life
Wilms Tumor