Ewha Med J.  1992 Dec;15(4):303-308. 10.12771/emj.1992.15.4.303.

Chronosomal Abnormalities in Patients with Hemato-Oncologic Disease: Analysis of 42 Cases

• Lee SN

• KMID: 1965136
• DOI: http://doi.org/10.12771/emj.1992.15.4.303

Abstract

With development of new technology such as handing technique and high resolution banding technique, cytogenetic examination has been utilized greatly in diagnosis and treatment of patients with hemato-oncologic diseases. Forty two patients with newly diagnosed and previously untreated hemato-oncologic diseases were examined for chromosomal abnormalities which included 11 cases of acute myelogenous leukemia(AML). 7 cases of acute lymphoblastic leukemia (ALL) and myelodyspalstic syndrome (MDS) each, 6 cases of chronic myelogenous leukemia (CML). 5 cases of other myelolproliferative disorders(MPD). 4 cases of non-Hodgkin's lymphoma(MHL). and 1 case each of aplastic anemia(AA) and malignant schwannoma(MS). Two cases of AML(18.2%) showed 45 XO and aneuploidy. Four cases of ALL(55.5%) showed chromosomal abnormalities : 3 cases with Philadelphia chromosome and 1 case with 45 XO. Only one case of MDS(14.3%) showed trisomy 8 and none of 3 cases which were converted to AML showed chromosomal abnormalities. Five cases of CML(83.3%) showed Philadelphia chromosome. Chromosomal abnormalities were not noted in cases of MPD, MHL, AA and MS. Collective studies of chromosomal abnormalities in hemato-onclologic diseases should be investigated further.

MeSH Terms

Aneuploidy
Chromosome Aberrations
Cytogenetic Analysis
Diagnosis
Hand
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Philadelphia Chromosome
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Trisomy