Cancer Res Treat.  2019 Jan;51(1):223-239. 10.4143/crt.2018.073.

Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer

Affiliations
  • 1Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea. hmodoctor@snubh.org
  • 2Department of Oncology/Hematology, School of Medicine, Kyungpook National University, Daegu, Korea.
  • 3Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Chonnam National University College of Medicine, Hwasun, Korea.
  • 4Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 5Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
  • 6Department of Internal Medicine, Keimyung University Dongsan Medical Center, Keimyung University College of Medicine, Daegu, Korea.
  • 7Department of Internal Medicine, Yeungnam University Medical Center, Yeungnam University College of Medicine, Daegu, Korea.
  • 8Department of Internal Medicine, Hallym University Medical Center, Hallym University, Anyang, Korea.
  • 9Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea.
  • 10Department of Internal Medicine, Chonbuk National University Hospital, Chonbuk National University Medical School, Jeonju, Korea.
  • 11Department of Hematology and Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
  • 12Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 13Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University College of Medicine, Yangsan, Korea.
  • 14Medical Department of Genzyme, Sanofi Korea, Seoul, Korea.

Abstract

PURPOSE
The purpose of this study was to evaluate chemotherapy patterns and changes in quality of life (QOL) during first-line palliative chemotherapy for Korean patients with unresectable or metastatic/recurrent gastric cancer (GC).
MATERIALS AND METHODS
Thiswas a non-interventional, multi-center, prospective, observational study of 527 patients in Korea. QOL assessments were conducted using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaires (QLQ)-C30 and QLQ-STO22 every 3 months over a 12-month period during first-line palliative chemotherapy. The specific chemotherapy regimens were selected by individual clinicians.
RESULTS
Most patients (93.2%) received combination chemotherapy (mainly fluoropyrimidine plus platinum) as their first-line palliative chemotherapy. The median progression-free survival and overall survival were 8.2 and 14.8 months, respectively. Overall, "a little" changes (differences of 5-10 points from baseline)were observed in some of the functioning or symptom scales; none of the QOL scales showed either "moderate" or "very much" change (i.e., ≥ 11 point difference from baseline). When examining the best change in each QOL domain from baseline, scales related to some aspects of functioning, global health status/QOL, and most symptoms revealed significant improvements (p < 0.05). Throughout the course of first-line palliative chemotherapy, most patients' QOL was maintained to a similar degree, regardless of their actual response to chemotherapy.
CONCLUSION
This observational study provides important information on the chemotherapy patterns and QOL changes in Korean patientswith advanced GC. Overall, first-line palliative chemotherapy was found to maintain QOL, and most parameters showed an improvement compared with the baseline at some point during the course.

Keyword

Advanced gastric cancer; First-line palliative chemotherapy; Quality of life

MeSH Terms

Disease-Free Survival
Drug Therapy*
Drug Therapy, Combination
Global Health
Humans
Korea
Observational Study
Prospective Studies
Quality of Life*
Stomach Neoplasms*
Weights and Measures

Figure

  • Fig. 1. Study flow chart.

  • Fig. 2. Overall (A) and progression-free survival (B) of first-line palliative chemotherapy. CI, confidence interval.

  • Fig. 3. Comparison of overall (A) and progression-free survival (B) of first-line palliative chemotherapy between patients aged < 70 and ≥ 70 years. CI, confidence interval.

  • Fig. 4. Changes in quality of life domains during first-line palliative chemotherapy. QLQ, Quality of Life Questionnaires; QOL, quality of life.


Cited by  1 articles

Chronological changes in quality of life and body composition after gastrectomy for locally advanced gastric cancer
Ki Bum Park, Ji Yeon Park, Seung Soo Lee, Ho Young Chung, Oh Kyoung Kwon
Ann Surg Treat Res. 2020;98(5):262-269.    doi: 10.4174/astr.2020.98.5.262.


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