J Korean Neurol Assoc.
2018 Nov;36(4):354-357. 10.17340/jkna.2018.4.17.
Bilateral Lesions in the Posterior Limb of Internal Capsule Attributed to Combination Therapy of Isoniazid and Rifampin
- Affiliations
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- 1Department of Neurology and Institute of Health Science, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, Korea. youngsookim0127@gmail.com, mnkwon21@daum.net
- 2Department of Neurology, Saetongyoung Hospital, Tongyoung, Korea.
- KMID: 2435851
- DOI: http://doi.org/10.17340/jkna.2018.4.17
Abstract
- Transient isoniazid-induced brain lesions have rarely been reported. The lesions were in the dentate nucleus of cerebellum and thalamus. Meanwhile, the neurotoxicity of rifampin has not been reported evidently. We observed bilateral lesions in the internal capsule in a young woman after taking a combination of isoniazid and rifampin. She transiently suffered numbness in both hands, dysarthria, and left side motor weakness while taking the medication. Isoniazid may induce structural lesions in various brain areas including the internal capsule.
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