J Biomed Transl Res.  2018 Dec;19(4):140-145. 10.12729/jbtr.2018.19.4.140.

Successful remission with L-CHOP for primary mediastinal B-cell lymphoma in a young Maltese dog

Affiliations
  • 1Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea. jhkang@chungbuk.ac.kr
  • 2Chungbuk National University-Johns Hopkins University Companion Animal-Based Translational Cancer Center (CATCC), Cheongju 28644, Korea.

Abstract

A one-year-old, intact female, Maltese dog was presented with a history of anorexia and regurgitation. Thoracic radiographs and ultrasonography scans suggested an abnormal mass in the cranial mediastinal region, and computed tomography confirmed the origin of this mass. Ultrasound-guided fine needle aspiration cytology showed the presence of intermediate to large lymphoid cells showing mitotic figures. B-cell lymphoma was confirmed by the result of a polymerase chain reaction assay for antigen receptor rearrangement, therefore the patient was diagnosed with primary mediastinal large B-cell lymphoma (PMBL). The patient underwent L-CHOP (L-asparaginase, cyclophosphamide, doxorubicin, vincristine, prednisolone)-based chemotherapy, and showed complete tumoral remission from the beginning of chemotherapy. Seventy-two weeks after the completion of chemotherapy, the patient is still alive without any evidence of metastasis or relapse. A standardized treatment protocol has yet to be established for primary mediastinal lymphoma in dogs. This case report describes the complete remission of PMBL by an L-CHOP-based chemotherapy protocol in a young Maltese. Clinicians should consider that L-CHOP based chemotherapy may be useful against PMBL in dogs.

Keyword

canine; lymphoma; chemotherapy; mediastinal mass; regurgitation

MeSH Terms

Animals
Anorexia
B-Lymphocytes*
Biopsy, Fine-Needle
Clinical Protocols
Cyclophosphamide
Dogs*
Doxorubicin
Drug Therapy
Female
Humans
Lymphocytes
Lymphoma
Lymphoma, B-Cell*
Neoplasm Metastasis
Polymerase Chain Reaction
Receptors, Antigen
Recurrence
Ultrasonography
Vincristine
Cyclophosphamide
Doxorubicin
Receptors, Antigen
Vincristine
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