Gastrointest Interv.  2018 Oct;7(3):158-161. 10.18528/gii180030.

Is glue embolization safe and effective for gastrointestinal bleeding?

• Yata S
• Ohuchi Y
• Adachi A
• Endo M
• Takasugi S
• Tsukamoto
• Matsumoto
• Kodani M
• Makishima
• Fujii S

• KMID: 2435016
• DOI: http://doi.org/10.18528/gii180030

Abstract

Transcatheter arterial embolization using N-butyl-2-cyanoacrylate (NBCA) for gastrointestinal arterial bleeding enables higher cessation rate and lower recurrent bleeding rate compared with conventional embolic materials including gelatin sponge, metallic coil, and polyvinyl alcohol (PVA) particle. Glue embolization is particularly effective in patients with coagulopathy. Even in the lower gastrointestinal tract, ischemic bowel complications by glue embolization are comparable to other agents. Glue embolization is also effective for arterial esophageal bleeding without any serious ischemic complications although the anatomy of the esophageal artery is complex and varied. For bleeding after abdominal surgery such as pancreaticoduodenectomy or hepatic lobectomy, interventional radiologists should be careful with indicating glue embolization because the presence of fewer collateral vessels can easily result in serious ischemic complications. Modified glue such as Glubran 2 (NBCA associated with methacryloxyfulfolane) can reduce the risk of ischemic complication due to its less thermal reaction, but the outcomes seem unsatisfactory.

Keyword

Cyanoacrylates; Gastrointestinal hemorrhage; Therapeutic embolization

MeSH Terms

Adhesives*
Arteries
Cyanoacrylates
Embolization, Therapeutic
Enbucrilate
Gastrointestinal Hemorrhage
Gelatin
Hemorrhage*
Humans
Lower Gastrointestinal Tract
Pancreaticoduodenectomy
Polyvinyl Alcohol
Porifera
Adhesives
Cyanoacrylates
Enbucrilate
Gelatin
Polyvinyl Alcohol