Biomed Eng Lett.
2018 Nov;8(4):393-398. 10.1007/s13534-018-0084-1.
Promotion of excisional wound repair by a menstrual blood-derived stem cell-seeded decellularized human amniotic membrane
- Affiliations
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- 1Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. msalehi.te1392@gmail.com
- 2Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran. farzamfar.saeed@razi.tums.ac.ir, avaez@razi.tums.ac.ir
- 3Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences, Shahroud, Iran. naseri.iranica@aut.ac.ir
- 4Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. zarnani@ari.ir, m_aleahmad@razi.tums.ac.ir
- 5Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
- 6Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran. hamed.sahrapeyma@srbiau.ac.ir
- 7Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. shokri.mr@tak.iums.ac.ir
- KMID: 2434890
- DOI: http://doi.org/10.1007/s13534-018-0084-1
Abstract
- This is the first study demonstrating the efficacy of menstrual blood-derived stem cell (MenSC) transplantation via decellularized human amniotic membrane (DAM), for the promotion of skin excisional wound repair. The DAM was seeded with MenSCs at the density of 3 × 10â´ cells/cm² and implanted onto a rat's 1.50 × 1.50 cm² full-thickness excisional wound defect. The results of wound closure and histopathological examinations demonstrated that the MenSC-seeded DAM could significantly improve the wound healing compared with DAM-treatment. All in all, our data indicated that the MenSCs can be a potential source for cell-based therapies to regenerate skin injuries.
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