J Korean Med Assoc.  2005 Jul;48(7):628-633. 10.5124/jkma.2005.48.7.628.

New Strategy of Ocular Surface Disease: Ocular Surface Reconstruction Using Amniotic Membrane and Limbal Stem Cell Transplantation

• Park WC

• KMID: 2183588
• DOI: http://doi.org/10.5124/jkma.2005.48.7.628

Abstract

Amniotic membrane is the innermost layer of the placenta and consists of a thick basement membrane and an avascular stromal matrix. Amniotic membrane transplantation facilitates rapid healing with recovery of a normal epithelial phenotype in the epithelium, and reduces inflammation, vascularization, and scarring in the stroma. Amniotic membrane has two major role, basement membrane and cocktail of cytokines. Amniotic membrane as a native matrix can be used as a graft to restore conjunctival surfaces and corneal surfaces suffering from intractable corneal disease or limbal stem cell deficiency. To restore limbal stem cell deficiency, the source of stem cell has been introduced the autograft transplantation, allograft transplantation, ex vivo expansion and in vivo expansion.

Keyword

Amniotic membrane; Limbal stem cell; Ocular surface reconstruction; Corneal surface; Conjunctival surface

MeSH Terms

Allografts
Amnion*
Autografts
Basement Membrane
Cicatrix
Corneal Diseases
Cytokines
Epithelium
Inflammation
Phenotype
Placenta
Stem Cell Transplantation*
Stem Cells*
Transplants
Cytokines

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