Psychiatry Investig.  2018 Dec;15(12):1121-1129. 10.30773/pi.2018.10.21.2.

Heritability and Familiality of MMPI Personality Dimensions in the Korean Families with Schizophrenia

• Jeong HJ
• Lee BD
• Park JM
• Lee YM
• Moon E
• Kim SY
• Lee KY
• Suh H
• Chung YI

• KMID: 2434760
• DOI: http://doi.org/10.30773/pi.2018.10.21.2

Abstract

OBJECTIVE
Categorical syndrome such as schizophrenia could be the complex of many continuous mental structure phenotypes including several personality development/degeneration dimensions. This is the study to search heritability and familiality of MMPI personality dimensions in the Korean schizophrenic LD (Linkage Disequilibrium) families.
METHODS
We have recruited 204 probands (with schizophrenia) with their parents and siblings whenever possible. We have used MMPI questionnaires for measuring personality and symptomatic dimensions. Heritabilities of personality dimensions in total 543 family members were estimated using Sequential Oligogenic Linkage Analysis Routines (SOLAR). Personality dimensions in total family members were compared with those in 307 healthy unrelated controls for measuring the familialities using ANOVA analysis.
RESULTS
Seven of the 10 MMPI variables were significantly heritable and were included in the subsequent analyses. The three groups (control, unaffected 1st degree relative, case) were found to be significantly different with the expected order of average group scores for all heritable dimensions.
CONCLUSION
Our results show that the aberrations in several personality dimensions could form the complexity of schizophrenic syndrome as a result of genetic-environment coactions or interactions in spite of some limitations (recruited family, phenotyping).

Keyword

Heritability; Familiality; MMPI; Dimension; Schizophrenia

MeSH Terms

Humans
MMPI*
Parents
Phenotype
Schizophrenia*
Siblings