Ann Lab Med.
2012 Nov;32(6):426-428.
Antifungal Susceptibility to Amphotericin B, Fluconazole, Voriconazole, and Flucytosine in Candida Bloodstream Isolates from 15 Tertiary Hospitals in Korea
- Affiliations
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- 1Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
- 2Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Korea. shinjh@chonnam.ac.kr
- 3Department of Laboratory Medicine, Ajou University College of Medicine, Suwon, Korea.
- 4Department of Laboratory Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
- 5Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea.
Abstract
- The in vitro antifungal susceptibility of 636 Candida bloodstream isolates collected from 15 tertiary hospitals in Korea was determined using the Vitek-2 yeast susceptibility system (bioMerieux, France). Overall susceptibility rates were 98.1%, 95.9%, 99.1%, and 97.3% for amphotericin B, fluconazole, voriconazole, and flucytosine, respectively. The results show that the rates of resistance to 4 antifungal drugs remain low among Candida bloodstream isolates in Korea.
Keyword
MeSH Terms
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Amphotericin B/*pharmacology
Antifungal Agents/*pharmacology
Candida/*drug effects/isolation & purification
Candidiasis/blood/microbiology
Fluconazole/*pharmacology
Flucytosine/*pharmacology
Humans
Microbial Sensitivity Tests
Pyrimidines/*pharmacology
Republic of Korea
Tertiary Care Centers
Triazoles/*pharmacology
Antifungal Agents
Pyrimidines
Triazoles
Amphotericin B
Flucytosine
Fluconazole
Reference
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1. Pfaller MA, Diekema DJ, Procop GW, Rinaldi MG. Multicenter comparison of the VITEK 2 antifungal susceptibility test with the CLSI broth microdilution reference method for testing amphotericin B, flucytosine, and voriconazole against Candida spp. J Clin Microbiol. 2007. 45:3522–3528.2. Pfaller MA, Diekema DJ, Procop GW, Rinaldi MG. Multicenter comparison of the VITEK 2 yeast susceptibility test with the CLSI broth microdilution reference method for testing fluconazole against Candida spp. J Clin Microbiol. 2007. 45:796–802.3. Bourgeois N, Dehandschoewercker L, Bertout S, Bousquet PJ, Rispail P, Lachaud L. Antifungal susceptibility of 205 Candida spp. isolated primarily during invasive candidiasis and comparison of the Vitek 2 system with the CLSI broth microdilution and Etest methods. J Clin Microbiol. 2010. 48:154–161.4. Shin JH, Kim MN, Jang SJ, Ju MY, Kim SH, Shin MG, et al. Detection of amphotericin B resistance in Candida haemulonii and closely-related species using the Etest, Vitek-2 Yeast Susceptibility System, and CLSI and EUCAST broth microdilution methods. J Clin Microbiol. 2012. 50:1852–1855.5. Jung SI, Shin JH, Song JH, Peck KR, Lee K, Kim MN, et al. Multicenter surveillance of species distribution and antifungal susceptibilities of Candida bloodstream isolates in South Korea. Med Mycol. 2010. 48:669–674.6. Messer SA, Jones RN, Moet GJ, Kirby JT, Castanheira M. Potency of anidulafungin compared to nine other antifungal agents tested against Candida spp., Cryptococcus spp., and Aspergillus spp.: results from the global SENTRY Antimicrobial Surveillance Program (2008). J Clin Microbiol. 2010. 48:2984–2987.
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