J Neurogastroenterol Motil.
2017 Apr;23(2):262-272. 10.5056/jnm16095.
Assessment of the Asian Neurogastroenterology and Motility Association Chronic Constipation Criteria: An Asian Multicenter Cross-sectional Study
- Affiliations
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- 1Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. slbclinic@gmail.com
- 2Biometrics Department, Janssen Cilag Benelux, Tilburg, The Netherlands.
- 3Regional Medical Affairs, Janssen Asia-Pacific, Singapore.
- 4Janssen EMEA, Issy-les-Moulineaux, France.
- 5Global Clinical Operations, Janssen, Selangor, Malaysia.
- 6Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
- 7Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University People's Hospital of Jiangsu Province, China.
- 8Department of Gastroenterology and Hepatology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
- 9Gastrointestinal Department, Peking University First Hospital, Beijing, China.
- 10University of Malaya, Kuala Lumpur, Malaysia.
- 11Department of Internal Medicine Section of Gastroenterology, St Luke's Medical Center, Institute of Digestive and Liver Diseases, Quezon, The Philippines.
- 12Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
- 13Institut des Maladies de l'Appareil Digestif, University Hospital of Nantes, Nantes, France.
- KMID: 2433527
- DOI: http://doi.org/10.5056/jnm16095
Abstract
- BACKGROUND/AIMS
There is a need for a simple and practical tool adapted for the diagnosis of chronic constipation (CC) in the Asian population. This study compared the Asian Neurogastroenterology and Motility Association (ANMA) CC tool and Rome III criteria for the diagnosis of CC in Asian subjects.
METHODS
This multicenter, cross-sectional study included subjects presenting at outpatient gastrointestinal clinics across Asia. Subjects with CC alert symptoms completed a combination Diagnosis Questionnaire to obtain a diagnosis based on 4 different diagnostic methods: self-defined, investigator's judgment, ANMA CC tool, and Rome III criteria. The primary endpoint was the level of agreement/disagreement between the ANMA CC diagnostic tool and Rome III criteria for the diagnosis of CC.
RESULTS
The primary analysis comprised of 449 subjects, 414 of whom had a positive diagnosis according to the ANMA CC tool. Rome III positive/ANMA positive and Rome III negative/ANMA negative diagnoses were reported in 76.8% and 7.8% of subjects, respectively, resulting in an overall percentage agreement of 84.6% between the 2 diagnostic methods. The overall percentage disagreement between these 2 diagnostic methods was 15.4%. A higher level of agreement was seen between the ANMA CC tool and self-defined (374 subjects [90.3%]) or investigator's judgment criteria (388 subjects [93.7%]) compared with the Rome III criteria.
CONCLUSION
This study demonstrates that the ANMA CC tool can be a useful for Asian patients with CC.
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