J Rhinol.  2018 Nov;25(2):91-98. 10.18787/jr.2018.25.2.91.

The Relationship between the Causative Allergens of Allergic Diseases and Environments in Korea Over a 8-Year-Period: Based on Skin Prick Test from 2006 to 2015

Affiliations
  • 1Department of Otorhinolaryngology-Head and Neck Surgery, St. Vincent's Hospital, Seoul, Korea.
  • 2Department of Otorhinolaryngology-Head and Neck Surgery, Uijeongbu St. Mary's Hospital, Uijeongbu, Korea.
  • 3Department of Otorhinolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, Seoul, Korea.
  • 4Department of Otorhinolaryngology-Head and Neck Surgery, Daejeon St. Mary's Hospital, The Catholic University of Korea, School of Medicine, Daejeon, Korea.
  • 5Department of Otorhinolaryngology-Head and Neck Surgery, Pusan St. Mary's Hospital, Pusan, Korea.
  • 6Department of Otorhinolaryngology-Head and Neck Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • 7Department of Otorhinolaryngology-Head and Neck Surgery, Gachon University, Gil Medical Center, Incheon, Korea.
  • 8Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Yeungnam University, Daegu, Korea.
  • 9Department of Otorhinolaryngology-Head and Neck Surgery, Jeju Hospital, Jeju University, College of Medicine, Jeju, Korea.
  • 10Department of Otorhinolaryngology-Head and Neck Surgery, Kun Kook University, School of Medicine, Seoul, Korea.
  • 11Department of Otorhinolaryngology-Head and Neck Surgery, Shinchon Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • 12Department of Otorhinolaryngology-Head and Neck Surgery, Ajou University School of Medicine, Suwon, Korea.
  • 13Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 14Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University, School of Medicine, Daejeon, Korea.
  • 15Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine, Yangsan, Korea.
  • 16Department of Otorhinolaryngology-Head and Neck Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea.
  • 17Department of Otorhinolaryngology-Head and Neck Surgery, The Catholic University of Daegu, School of Medicine, Daegu, Korea.
  • 18Department of Otorhinolaryngology-Head and Neck Surgery, Chonnam National University Medical School, Gwangju, Korea.
  • 19Department of Otorhinolaryngology-Head and Neck Surgery, Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Korea.
  • 20Department of Otorhinolaryngology-Head and Neck Surgery, Guro Hospital, Korea University, School of Medicine, Seoul, Korea.
  • 21Department of Otorhinolaryngology-Head and Neck Surgery, Yeouido St. Mary's Hospital, Seoul, Korea. entcho@catholic.ac.kr

Abstract

BACKGROUND AND OBJECTIVES
The present study evaluated the results of skin prick test using 55 allergens at 20 centers in the Republic of Korea in 2006, 2010, and 2014-2015. The aim was to assess changes in the positive rate of allergens according to temporal, regional, and environmental factors.
MATERIALS AND METHODS
In total, 20 hospitals were selected based on the population distribution in the Republic of Korea. A skin prick test panel comprising 55 aeroallergens was distributed to 18 hospitals for this prospective study. The 2006 and 2010 skin prick test results were collected and analyzed retrospectively from 20 hospitals, while the 2014/2015 skin prick test results (from June 2014 to May 2015) were collected prospectively from 18 hospitals.
RESULTS
A total of 14,897 SPT test results were analyzed: 4,319 in 2006, 7,431 in 2010, and 1,852 in 2014/2015. The overall rate of skin prick test positivity to more than two allergens was significantly higher in males than females. The positive rates of alder pollens and birch, oak and ragweed pollen positivity were increased in older patients. Several positive rates were increased according to the temperature in spring. The positive rates for beech pollen, birch pollen, hazel pollen, oak pollen, Tyrophagus putrescentiae, mugwort, cat, Acarus siro, Lepidoglyphus destructor and Tyrophagus putrescentiae were significantly increased, while those of Cult rye pollen and dandelion were significantly decreased over the three test periods. The overall positive rate for allergens in Jeju province varied significantly from Seoul and other cities.
CONCLUSION
Change in the positive rate of multiple aeroallergens was evaluated in the Republic of Korea over time. Our findings can be used to recommend aeroallergens suitable for inclusion in skin prick test panels in the Republic of Korea and will facilitate further investigation of changes in the patterns of allergic diseases.

Keyword

Skin prick test; Aeroallergen

MeSH Terms

Allergens*
Alnus
Ambrosia
Animals
Artemisia
Betula
Cats
Demography
Fagus
Female
Humans
Korea*
Male
Mites
Pollen
Prospective Studies
Republic of Korea
Retrospective Studies
Secale
Seoul
Skin*
Taraxacum
Allergens

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