Korean Lepr Bull.  2018 Dec;51(1):13-21. 10.33161/klb.2018.51.1.13.

Seropositivity of Hepatitis C Virus among Persons affected Leprosy in Korea

• Kim JP
• Kang KH
• Park JM

• KMID: 2429659
• DOI: http://doi.org/10.33161/klb.2018.51.1.13

Abstract

BACKGROUND
Leprosy is a contagious chronic granulomatous disease and is a disease that is associated with defects in cellular immunity. A high prevalence of hepatitis C virus infection in leprosy patients has been reported in several African countries, Yemen, Brazil and Japan. In Korea, it's seropositivity was reported as 8.33%(2001), 39.3%(2002), 35.1%(2009) and 16.0%(2009) on Korean Leprosy Bulletin.
OBJECTIVE
In the meantime, the studies were limited to the subjects in a specific region, and the number of subjects was not enough, so it was not enough to evaluate the hepatitis C virus seropositivity of persons affected by leprosy in Korea. So this study was conducted to evaluate the it's seropositivity in settlement villages nationwide. METHOD: This study was conducted that the mobile team visited the resettlement villages nationwide from 2009 to 2017 and conducted on persons affected by leprosy and residents residing in resettlement village. Obtained serums were assayed by the ADVIA Centaur HVC(IgG antibodies to Hepatitis C Virus) reagent using a Siemens ADVIA Centaur CP instrument. The results of persons affected by leprosy and residents were compared, and the difference of seropositivity among the groups(male and female, multibacillary and paucibacillary, locations of resettlement villages) was evaluated. RESULT: The results of hepatitis C virus antibody positivity of 1669 persons affected by leprosy subjects and 185 residents of resettlement villages were 28.46% in persons affected by leprosy and 6.49% in residents(Pearson's Chi-Square test, P = 0.00). In persons affected by leprosy, that were 31.99%(male) and 26.84%(female)(Pearson's Chi-Square test, P = 0.06) and were 29.97%(multibacillary) and 25.36%(paucibacillary)(Pearson's Chi-Square test, P = 0.05). That of Seoul(48.28%), Busan(43.78%) and Chungbuk Province(35.94%) were highly positive and that of Gangwon Province(20.34%) was lowly positive(Fisher's Exact test P = 0.002).
CONCLUSION
In this study, we found that hepatitis C virus antibody positivity rate was high in persons affected by leprosy in Korea. In order to explain the high positive rate, further studies will be needed. Also, through various approaches including assessment of HCV RNA to the subjects who were judged to be positive for antibody test in the future, a comprehensive evaluation of hepatitis C and its countermeasures are needed.

Keyword

Hepatitis C virus; Leprosy; Seropositivity

MeSH Terms

Antibodies
Brazil
Chungcheongbuk-do
Female
Gangwon-do
Granulomatous Disease, Chronic
Hepacivirus*
Hepatitis C*
Hepatitis*
Humans
Immunity, Cellular
Japan
Korea*
Leprosy*
Methods
Prevalence
RNA
Yemen
Antibodies
RNA

Figure

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  Fig. 1. Comparison of seropositivity between age groups of PALs*PALs* ; Persons by affected leprosy

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  Fig. 2. Comparison of seropositivity among locations of villages, PALs* (observed & standardized)PALs* ; Persons by affected leprosy

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