Investig Clin Urol.  2016 May;57(3):191-195. 10.4111/icu.2016.57.3.191.

The histologic features of intratubular germ cell neoplasia and its correlation with tumor behavior

• Basiri A
• Movahhed S
• Parvin M
• Salimi M
• Rezaeetalab GH

• KMID: 2426493
• DOI: http://doi.org/10.4111/icu.2016.57.3.191

Abstract

PURPOSE
To assess the prevalence of intratubular germ cell neoplasia (ITGCN) in patients with concurrent testis tumor and its correlation with histologic features and serum tumor markers.
MATERIALS AND METHODS
From 2003 to 2015, 179 patients underwent radical orchiectomy due to testicular mass. Tissue specimens were evaluated by an expert uro-pathologist using immunohistochemistry (IHC) staining, in addition to light microscopy, to identify presence of ITGCN. Patients' demographic characteristics, histologic subtypes, pathologic stage of tumor and serum tumor markers were gathered and analyzed.
RESULTS
Eighty-five out of 179 patients (47.5%) had concomitant ITGCN according to IHC staining. There was not statistically significant difference in histologic type, histologic components, cryptorchidism, and lymphovascular invasion between the 2 groups (p=0.151, p=0.11, p=0.233, p=0.413, and p=0.14, respectively). The prevalence of ITGCN was significantly higher in patients with stage T2 and T3 of tumor than those with stage T1. Elevated serum alpha feto protein level is much common in patients with ITGCN (p<0.001).
CONCLUSIONS
The prevalence of concurrent ITGCN in our region is lower than previous data from western countries. ITGCN is more common in higher tumor stages and is accompanied with elevated serum alpha feto protein levels before surgery. Presence of ITGCN in adjacent tissue may suggest a negative cancer behavior.

Keyword

Germ cell and embryonal neoplasms; Seminoma; Testicular neoplasms

MeSH Terms

Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor/blood
Child
Child, Preschool
Cross-Sectional Studies
Humans
Infant
Iran/epidemiology
Male
Middle Aged
Neoplasm Staging
Neoplasms, Germ Cell and Embryonal/epidemiology/*pathology
Orchiectomy
Precancerous Conditions/epidemiology/*pathology
Prevalence
Seminoma/epidemiology/pathology/surgery
Testicular Neoplasms/epidemiology/*pathology/surgery
Young Adult
alpha-Fetoproteins/analysis

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