J Korean Pain Soc.  1998 Oct;11(2):258-262.

The Comparative Study of Butorphanol Versus Ketoprofen: Effect and Safety in Postoperative Pain Control after Hysterectomy

• Lim YJ
• Lee SC

Abstract

BACKGROUND: In view of the safety and effectiveness of butorphanol as a postoperative analgesic,. we designed' to compare its activity and side effects with those of ketoprofen, when adtniniitenxi. intra- muscularly.
METHODS
Nmety four patiaits, scheduled for elective total abdominal hystomy, received eitlier. ketoprofen 100 mg (ketoprofen group) or butorphanol 2 mg (butorphanol group) intramuscularly after surgery. For the first six hours after injection of butorphanol or ketoprofen, the patimts were asked to reevaluate the intensity of pain, using numeric rating scale (NRS) and pain score. If the pain score was above 2, supplemental ketoprofen was administered IM. Incidence of side effects were also cheoked.
RESULTS
Butorphanol group showed lower NRS and pain score for the first four hours compared to ketoprofen group, but the incidence of drowsiness was higher in butorphanol group. there were no significant difference in the incidence of other side effects such as nausea and dizziness. In both gmup, there were neither respiratory depression nor pruritus.
CONCLUSIONS
Butorphanol gave better relief of postoperative pain compared to ketoprafen. Butorphanol might be a useful drug for postoperative analgesia after hysterectomy with minor side effects.

Keyword

Analgesics, ketoprofen, butorphanol; Pain, postoperative

MeSH Terms

Analgesia
Butorphanol*
Dizziness
Hysterectomy*
Incidence
Ketoprofen*
Nausea
Pain, Postoperative*
Pruritus
Respiratory Insufficiency
Sleep Stages
Butorphanol
Ketoprofen