Korean J Med.  2003 Jun;64(6):690-694.

A case of mixed prolactin and growth hormone-secreting pituitary microadenoma presenting galactorrhea

• Koh MB
• Park JH
• Park YW
• Chang SA
• Min KO
• Seo EJ
• Son HY

Abstract

We report a case of galactorrhea with acromegaly from the mixed prolactin and GH secreting pituitary microadenoma managed with a successful surgical complete removal. A 31-year-old woman visited our hospital complaining galactorrhea for more than 6 months after delivery. The physical findings of the patient were a prominent galactorrhea and mild acromegalic features of face and extremities. The laboratory findings of hematology and blood chemistry were normal. In addition, the basal levels of prolactin and GH were slightly elevated. The thyroid is in euthyroid state. The results of the combined anterior pituitary hormone-stimulation tests were that the prolactin and GH responses were stimulated exaggeratedly and the other hormonal ones were normal responses. The oral glucose loading test for acromegaly revealed non-responder results. The sellar MRI showed the 6 X 5 mm-sized pituitary microadenoma. She was operated for surgical removal of the lesions of which the immunohistochemistry findings were consistent with the positive findings for both prolactin and GH. She discharged without post-operative complication and has done well with normalized hormonal levels at outpatient department.

Keyword

Galactorrhea; Acromegaly; Pituitary neoplasm

MeSH Terms

Acromegaly
Adult
Chemistry
Extremities
Female
Galactorrhea*
Glucose
Hematology
Humans
Immunohistochemistry
Magnetic Resonance Imaging
Outpatients
Pituitary Neoplasms
Pregnancy
Prolactin*
Thyroid Gland
Glucose
Prolactin