J Korean Orthop Assoc.  2018 Oct;53(5):375-380. 10.4055/jkoa.2018.53.5.375.

Non-Operative Management of Musculoskeletal Diseases and Regenerative Medicine

• Oh JH
• Rhee SM

• KMID: 2424095
• DOI: http://doi.org/10.4055/jkoa.2018.53.5.375

Abstract

Recently, due to the unsatisfactory outcomes of several orthopedic surgical procedures, non-operative management of musculoskeletal diseases, including regenerative medicine, is becoming more attractive to orthopedic surgeons. Regarding the healing of musculoskeletal tissues, such as bone, cartilage and tendons, regenerative medicine aims to replace or promote tissue regeneration. Among them, therapy using stem cells, prolotherapy, platelet-rich plasma, and extracorporeal shockwave therapy are taking center stage. Numerous animal and clinical studies have been published and the number has increased exponentially in recent years. On the other hand, because regenerative medicine in the orthopedic field is still in the early stages, no definite methods for the procedures have been made and there is some controversy regarding their application to musculoskeletal disease. Therefore, more high quality studies including randomized studies should be performed to establish standards and evaluate their value in the orthopedic field.

Keyword

regenerative medicine; stem cell; prolotherapy; platelet-rich plasma; extracorporeal shockwave therapy

MeSH Terms

Animals
Cartilage
Hand
Musculoskeletal Diseases*
Orthopedic Procedures
Orthopedics
Platelet-Rich Plasma
Regeneration
Regenerative Medicine*
Stem Cells
Surgeons
Tendons

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