J Korean Acad Prosthodont.  2018 Oct;56(4):391-395. 10.4047/jkap.2018.56.4.391.

A review of biocompatibility of zirconia: In vitro experiment

Affiliations
  • 1School of Dentistry, Seoul National University, Seoul, Republic of Korea.
  • 2Department of Oral & Maxillofacial Surgery, Seoul National University Bundang Hospital, Seongnam, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
  • 3Department of Prosthodontics, Seoul National University Bundang Hospital, Seongnam, School of Dentistry, Seoul National University, Seoul, Republic of Korea. navydent@snubh.org

Abstract

Increasing demands for zirconia material in clinics, assessment of biocompatibility of zirconia is essential. In this article, a review of in vitro studies of zirconia compatibility was performed. Zirconia showed great biocompatibility at in vitro studies with various cell lines such as fibroblasts, osteoblasts, and lymphocytes. Many studies reported that zirconia caused no cytotoxicity or mutation. Zirconia also showed less bacterial adhesion. There were no adverse effects except for small reduced strength with in vitro study mimicking long-term exposure of body fluid. According to the study with ostoblast-like cells, zirconia could regulate genes of immunity, molecular transport, and cell cycle. Such gene regulating was considered as one of the reasons of zirconia biocompatibility. With biocompatibility of zirconia powders, in vitro studies had controversial conclusions. It seems that zirconia powders might have cytotoxicity

Keyword

Biocompatibility; Cytotoxicity; Zirconia

MeSH Terms

Bacterial Adhesion
Body Fluids
Cell Cycle
Cell Line
Fibroblasts
In Vitro Techniques*
Lymphocytes
Osteoblasts
Powders
Powders
Full Text Links
  • JKAP
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2022 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr