Ann Pediatr Endocrinol Metab.  2018 Sep;23(3):148-153. 10.6065/apem.2018.23.3.148.

Factors affecting height velocity in normal prepubertal children

• Lee JH
• Kim SK
• Lee EK
• Ahn MB
• Kim SH
• Cho WK
• Cho KS
• Jung MH
• Suh BK

• KMID: 2422479
• DOI: http://doi.org/10.6065/apem.2018.23.3.148

Abstract

PURPOSE
To analyze the effects of clinical and laboratory factors, including insulin-like growth factor (IGF) levels, on the height velocity of normal prepubertal children.
METHODS
Ninety-five healthy prepubertal children (33 boys, 62 girls) were enrolled. The mean chronological age was 6.3±1.4 years, with a height standard deviation score (SDS) of -0.88±0.70. IGF-1, IGF binding protein-3 (IGFBP-3), SDS for anthropometric measurements, and changes in SDS for anthropometric measurements were analyzed for 1 year, and their associations with 1-year height velocity were investigated.
RESULTS
The group of children with a 1-year height velocity of ≥6 cm were chronologically younger than the group with a 1-year height velocity of < 6 cm (5.9±1.3 years vs. 6.7±1.3 years, P=0.004), with a lesser increase of SDS for body mass index (BMI) over 1 year (-0.18±0.68 vs. 0.13±0.53, P=0.014). There were no differences between the 2 groups in IGF-1 SDS and IGFBP-3 SDS. Multiple linear regression showed that baseline chronological age (r=0.243, P=0.026) and height SDS (r=0.236, P=0.030) were positively associated with IGF-1 SDS. Binomial logistic regression showed that an older chronologic age at referral (odds ratio [OR], 0.68; 95% confidence interval [CI], 0.47-0.99) and an increase of BMI SDS over 1 year (OR, 0.41; 95% CI, 0.18-0.89) were associated with a decreased growth possibility of an above-average height velocity (≥6 cm/yr).
CONCLUSIONS
Height velocity of normal prepubertal children is affected by an increase of BMI SDS and chronological age. Prepubertal IGF-1 SDS reflects height SDS at the time of measurement but is not associated with subsequent height velocity.

Keyword

Height velocity; Body mass index; Insulin-like growth factor; Normal prepubertal children

MeSH Terms

Body Mass Index
Child*
Humans
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Linear Models
Logistic Models
Referral and Consultation
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I

Figure

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  Fig. 1. Body mass index (BMI), weight and height standard deviation score (SDS) changes over 1 year.

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  Fig. 2. Distribution of clinical parameters according to insulin-like growth factor-1 (IGF-1) standard deviation score (SDS). eCA, chronological age at referral; eWt, weight at referral; eBMI, body mass index at referral.

Reference

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