J Korean Assoc Pediatr Surg.  1998 Dec;4(2):131-136. 10.13029/jkaps.1998.4.2.131.

Therapeutic Effect of OK-432 for Lymphangioma in Children

• Jung SE
• Kim DY
• Shim IB
• Lee SC
• Park KW
• Kim WK

• KMID: 2422200
• DOI: http://doi.org/10.13029/jkaps.1998.4.2.131

Abstract

Lymphangioma is a congenital malformation of the lymphatic system that expands into the surrounding tissues in a manner similar to a malignant tumor. Surgical excision has been the treatment of choice, but the results are often unsatisfactory due to incomplete resection, fluid collection and recurrences. Intralesional injection of OK-432(lyophilized incubation mixture of Group A Streptococcus pyogenes of human origin) was employed in treating 24 patients with lymphangiomas between 1992 and 1997. The method was used in 21 patients as a primary therapy, and in 3 patients for unresectable or recurrent cases as a secondary treatment. The results were excellent in 8 patients (33.3 %), good in 7 patients (21.8 %) and poor in 7 patients (21.8 %). The side effects were fever under 39℃ and local inflammation. However these symptoms subsided in a few days without serious sequelae. These results suggest that intralesional injection of OK -432 is safe and effective treatment for primary lymphangioma as well as a secondary therapy for unresectable or recurrent cases.

Keyword

Lymphangioma; OK-432

MeSH Terms

Child*
Fever
Humans
Inflammation
Injections, Intralesional
Lymphangioma*
Lymphatic System
Methods
Picibanil*
Recurrence
Streptococcus pyogenes
Picibanil