J Korean Assoc Pediatr Surg.  1999 Jun;5(1):1-14. 10.13029/jkaps.1999.5.1.1.

Teratomas in Children

Affiliations
  • 1Department of Surgery, College of Medicine, Hanyang University, Seoul, Korea.

Abstract

Among 60 children with teratoma, forty-three (71.7 percent) were girls and 17 (28.3 percent) boys. Primary sites were sacrococcygeal in 30 patients (50 percent), retroperitoneal in 12 (20 percent), ovarian in 11 (18.3 percent), testicular in 3 (5 percent), and one in each of nasopharyngeal, gastric, hepatic and pancreatic (1.6 percent, respectively). Fifty-five (91.7 percent) teratomas were benign and 5 (8.3 percent) malignant. Malignant teratomas were detected only at sacrococcygeal region (16.7 percent). Older than 2 months of age at diagnosis, presence of urinary and colonic obstructive symptoms, multiple masses and elevated serum alpha-fetoprotein were indicators of malignancy in sacrococcygeal region. Tumor size, presence of calcification, and gross appearance (cystic or solid) did not correlate with malignant nature. Thirteen (21.7 percent) cases were associated with other anomalies. For the immature teratoma, the operative resection without adjuvant chemotherapy was enough. Three malignant cases were survived, one with chemotheapy for 3 years and the others without chemotherapy for 5 and 10 years.

Keyword

Teratoma; Fetus-in-fetu; Endodermal sinus tumor; Embryonal carcinoma

MeSH Terms

alpha-Fetoproteins
Carcinoma, Embryonal
Chemotherapy, Adjuvant
Child*
Colon
Diagnosis
Drug Therapy
Endodermal Sinus Tumor
Female
Humans
Sacrococcygeal Region
Teratoma*
alpha-Fetoproteins
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