J Vet Sci.  2018 Sep;19(5):721-724. 10.4142/jvs.2018.19.5.721.

Detection and genetic characterization of porcine circovirus 3 from aborted fetuses and pigs with respiratory disease in Korea

• Kim SH
• Park JY
• Jung JY
• Kim HY
• Park YR
• Lee KK
• Lyoo YS
• Yeo SG
• Park CK

• KMID: 2420943
• DOI: http://doi.org/10.4142/jvs.2018.19.5.721

Abstract

A novel porcine circovirus 3 (PCV3) was first detected in pigs showing porcine dermatitis and nephropathy syndrome, reproductive failure, and multisystemic inflammation in the USA. Herein, we report on PCV3 as a potential etiological agent of clinical signs, reproductive failure and respiratory distress on Korean pig farms, based on in situ hybridization, pathological, and molecular findings. Confirmation of the presence of PCV3 may increase co-infection with other causative agents of disease in Korean pig herds, indicating the need for further systemic investigation of pathogenicity and of multiple infections with PCV2 genotypes and bacteria, and the development of an effective PCV3 vaccine.

Keyword

Korea; porcine circovirus 3; reproductive failure and respiratory distress

MeSH Terms

Aborted Fetus*
Agriculture
Bacteria
Circovirus*
Coinfection
Dermatitis
Genotype
In Situ Hybridization
Inflammation
Korea*
Swine*
Virulence

Figure

• 

  Fig. 1 Detection of porcine circovirus 3 mRNA (arrows) in lung alveolar macrophages by in situ hybridization. Scale bar = 100 µm.

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  Fig. 2 Phylogenetic analysis of the complete genomes of two Korean porcine circovirus 3 (PCV3) strains and two reference strains, PCV2a-e and PCV3, available in GenBank. The PCV3 viruses used in this study are shown in red. The viruses in bold were detected in Korea. Numbers at branches represent bootstrap values greater than 50% of replicates.

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