Tuberc Respir Dis.  2018 Jan;81(1):42-48. 10.4046/trd.2017.0118.

Development of Prediction Equation of Diffusing Capacity of Lung for Koreans

Affiliations
  • 1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.
  • 2Lung Research Institute of Hallym University College of Medicine, Chuncheon, Korea.
  • 3Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea.
  • 4Division of Pulmonology, Critical Care and Sleep Medicine, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 5Division of Pulmonary and Critical Care Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 6Division of Pulmonology, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
  • 7Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ajou University School of Medicine, Suwon, Korea.
  • 8Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
  • 9Division of Pulmonary, Allergy and Critical Care Medicine, Chonbuk National University Hospital, Chonbuk National University Medical School, Jeonju, Korea.
  • 10Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 11Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea.
  • 12Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Korea.
  • 13Regional Center for Respiratory Disease, Yeungnam University Medical Center, Yeungnam University College of Medicine, Daegu, Korea.
  • 14Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
  • 15Division of Pulmonary and Critical Care Medicine, Wonkwang University Sanbon Hospital, Wonkwang University School of Medicine, Gunpo, Korea.
  • 16Department of Clinical Pharmacology, Konkuk University School of Medicine, Seoul, Korea.
  • 17Department of Internal Medicine, Konkuk University Medical Center, Seoul, Korea. khyou@kuh.ac.kr
  • 18Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea. jaejshim@kumc.or.kr

Abstract

BACKGROUND
The diffusing capacity of the lung is influenced by multiple factors such as age, sex, height, weight, ethnicity and smoking status. Although a prediction equation for the diffusing capacity of Korea was proposed in the mid-1980s, this equation is not used currently. The aim of this study was to develop a new prediction equation for the diffusing capacity for Koreans.
METHODS
Using the data of the Korean National Health and Nutrition Examination Survey, a total of 140 nonsmokers with normal chest X-rays were enrolled in this study.
RESULTS
Using linear regression analysis, a new predicting equation for diffusing capacity was developed. For men, the following new equations were developed: carbon monoxide diffusing capacity (DLco)=−10.4433−0.1434×age (year)+0.2482×heights (cm); DLco/alveolar volume (VA)=6.01507−0.02374×age (year)−0.00233×heights (cm). For women the prediction equations were described as followed: DLco=−12.8895−0.0532×age (year)+0.2145×heights (cm) and DLco/VA=7.69516−0.02219×age (year)−0.01377×heights (cm). All equations were internally validated by k-fold cross validation method.
CONCLUSION
In this study, we developed new prediction equations for the diffusing capacity of the lungs of Koreans. A further study is needed to validate the new predicting equation for diffusing capacity.

Keyword

Korean; Pulmonary Diffusing Capacity; Diffusion; Carbon Monoxide

MeSH Terms

Carbon Monoxide
Diffusion
Female
Humans
Korea
Linear Models
Lung*
Male
Methods
Nutrition Surveys
Pulmonary Diffusing Capacity
Smoke
Smoking
Thorax
Carbon Monoxide
Smoke

Reference

1. Gold WM. Pulmonary function testing. In : Mason RJ, Broaddus VC, Murray JF, Nadel JA, editors. Murray and Nadel's textbook of respiratory medicine. 4th ed. Philadelphia: Elsevier Saunders;2005. p. 695–703.
2. Macintyre N, Crapo RO, Viegi G, Johnson DC, van der Grinten CP, Brusasco V, et al. Standardisation of the single-breath determination of carbon monoxide uptake in the lung. Eur Respir J. 2005; 26:720–735. PMID: 16204605.
Article
3. Crapo RO, Gardner RM. DLCO reference equations: a perspective. Am Rev Respir Dis. 1986; 134:856. PMID: 3777680.
4. Yang SC, Yang SP, Lin PJ. Prediction equations for single-breath carbon monoxide diffusing capacity from a Chinese population. Am Rev Respir Dis. 1993; 147:599–606. PMID: 8442593.
Article
5. Korotzer B, Ong S, Hansen JE. Ethnic differences in pulmonary function in healthy nonsmoking Asian-Americans and European-Americans. Am J Respir Crit Care Med. 2000; 161(4 Pt 1):1101–1108. PMID: 10764297.
Article
6. Pesola GR, Huggins G, Sherpa TY. Abnormal predicted diffusion capacities in healthy Asians: an inequality with a solution. Respiration. 2006; 73:799–807. PMID: 16825753.
Article
7. Chhabra SK, Kumar R, Gupta UA. Prediction equations for diffusing capacity (transfer factor) of lung for North Indians. Lung India. 2016; 33:479–486. PMID: 27625439.
Article
8. Park JO, Choi IS, Park KO. Normal predicted values of single-breath diffusing capacity of the lung in healthy nonsmoking adults. Korean J Intern Med. 1986; 1:178–184. PMID: 3154613.
Article
9. Song EH, Oh YM, Hong SB, Shim TS, Lim CM, Lee SD, et al. Selection of reference equations for lung volumes and diffusing capacity in Korea. Tuberc Respir Dis. 2006; 61:218–226.
Article
10. Ra SW, Park TS, Hong Y, Hong SB, Shim TS, Lim CM, et al. Clinical usefulness and the accuracy of Korean reference equation for diffusing capacity. Tuberc Respir Dis. 2008; 64:80–86.
Article
11. Burrows B, Kasik JE, Niden AH, Barclay WR. Clinical usefulness of the single-breath pulmonucy diffusing capacity test. Am Rev Respir Dis. 1961; 84:789–806. PMID: 13875021.
12. Crapo RO, Morris AH. Standardized single breath normal values for carbon monoxide diffusing capacity. Am Rev Respir Dis. 1981; 123:185–189. PMID: 7235357.
13. Paoletti P, Viegi G, Pistelli G, Di Pede F, Fazzi P, Polato R, et al. Reference equations for the single-breath diffusing capacity: a cross-sectional analysis and effect of body size and age. Am Rev Respir Dis. 1985; 132:806–813. PMID: 3876793.
14. Roca J, Rodriguez-Roisin R, Cobo E, Burgos F, Perez J, Clausen JL. Single-breath carbon monoxide diffusing capacity prediction equations from a Mediterranean population. Am Rev Respir Dis. 1990; 141(4 Pt 1):1026–1032. PMID: 2327636.
Article
15. Standardization of lung function tests. Report working party. Bull Eur Physiopathol Respir. 1983; 19(Suppl 5):1–95. PMID: 6616097.
16. Korean Center for Disease Control and Prevention. Korean National Health & Nutrition Examination Survey. Cheongju: Korean Center for Disease Control and Prevention;2017. cited 2017 Oct 10. Available from: https://knhanes.cdc.go.kr/knhanes/main.do.
17. Hwang YI, Park YB, Yoo KH. Recent trends in the prevalence of chronic obstructive pulmonary disease in Korea. Tuberc Respir Dis. 2017; 80:226–229.
Article
18. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of spirometry. Eur Respir J. 2005; 26:319–338. PMID: 16055882.
19. Choi JK, Paek D, Lee JO. Normal predictive values of spirometry in Korean population. Tuberc Respir Dis. 2005; 58:230–242.
Article
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