Korean J Intern Med.  2018 Sep;33(5):922-932. 10.3904/kjim.2016.368.

Early experience and favorable clinical outcomes of everolimus-eluting bioresorbable scaffolds for coronary artery disease in Korea

• Kwon O
• Ahn JM
• Kang DY
• Kang SH
• Lee PH
• Kang SJ
• Lee SW
• Kim YH
• Lee CW
• Park SW
• Park DW
• Park SJ

• KMID: 2420004
• DOI: http://doi.org/10.3904/kjim.2016.368

Abstract

BACKGROUND/AIMS
Compared with metallic drug-eluting stents (DES), bioresorbable vascular scaffolds (BVS) may further improve long-term outcomes of percutaneous coronary intervention (PCI) in patients with coronary artery disease. We report our early experience with BVS in Korea.
METHODS
We evaluated 105 consecutive patients with BVS implanted at Asan Medical Center, Korea between October 21, 2015 and June 3, 2016. Angiographic results, and in-hospital and 6-month clinical outcomes were assessed.
RESULTS
A total of 134 BVS were implanted to treat 115 lesions. The mean age was 62 ± 10.5 years; 85 patients (81%) were males, 26 patients (25%) were presented with acute coronary syndrome. Among 115 lesions treated with BVS, 76 (66.1%) were B2/C type, 27 (23.5%) were bifurcation lesions, and four (3.5%) were chronic total occlusion. Pre-dilation and post-dilation using high-pressure non-compliant balloon was performed in 104 lesions (90.4%) and 113 lesions (98.2%), respectively. During the procedure, intravascular imaging was used for all patients (100%; intravascular ultrasound 89 and optical coherence tomography 40 patients). Device success rate was 100%. In-segment and in-scaffold acute again were 1.1 ± 0.6 and 1.3 ± 0.5 mm, respectively. Periprocedural myocardial infraction occurred in four patients (3.8%). No deaths, stent thrombosis, or urgent revascularizations occurred either during hospitalization or the follow-up period.
CONCLUSIONS
In this single-center experience, implantation of BVS with intravascular imaging support was feasible and early clinical outcomes were excellent. Evaluation of long-term efficacy and safety of BVS and its feasibility in clinical use for a broader range of lesions is warranted.

Keyword

Absorbable implants; Bioresorbable vascular scaffolds; Percutaneous coronary intervention

MeSH Terms

Absorbable Implants
Acute Coronary Syndrome
Chungcheongnam-do
Coronary Artery Disease*
Coronary Vessels*
Drug-Eluting Stents
Endovascular Procedures
Follow-Up Studies
Hospitalization
Humans
Korea*
Male
Percutaneous Coronary Intervention
Stents
Thrombosis
Tomography, Optical Coherence
Ultrasonography