J Korean Soc Radiol.  2010 Aug;63(2):189-192.

Myoid Hamartoma of the Breast: A Case Report

• Jeh SK
• Kang BJ
• Kim SH
• Cha ES
• Kim TJ

Abstract

Myoid (muscular) hamartoma is a rare subtype of hamartoma and is characterized by the presence of smooth muscle cells. We report a case of myoid hamartoma presenting as a large palpable mass in a 28-year-old patient, which was confirmed by surgical excision and pathologic diagnosis.

MeSH Terms

Adult
Breast Neoplasms
Hamartoma
Humans
Mammography
Myocytes, Smooth Muscle

Figure

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  Fig. 1 Mammography Findings. Craniocaudal (A), and mediolateral oblique (B) mammogram showed no remarkable mass shadow, except for a slightly bulging contour of the upper portion of the left breast on mediolateral oblique mammogram (white arrow).

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  Fig. 2 Ultrasonographic Findings. Longitudinal (A), transverse (B), and color Doppler (C) ultrasonogram revealed an isoechoic solid mass with focal inhomogeneously low echogenicity (white arrow). The mass had a lobulated shape, focal angular and microobulated margin (black arrows), as well as increased vascularity at the peripheral portion.

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  Fig. 3 Pathologic Findings. A. On H & E stain, the mass contained a smooth muscle cell bundle (black arrow) mixed with lobular structures (white arrow) and dilated ducts (asterisks) (H & E stain, ×20). B, C. Immunohistochemical staining of action (B), and heavy chain smooth muscle myosin (C) showed a strong positive finding (brown color).

Reference

1. Kang BS, Park JM. Muscular Hamartoma of the Breast: A Case Report. J Korean Radiol Soc. 2002; 47:99–101.

2. Stafyla V, Kotsifopoulos N, Grigoriadis K, Bokoyiannis CN, Peros G, Sakorafas GH. Myoid hamartoma of the breast : a case report and review of the literature. Breast J. 2007; 13:85–87.

3. Shepstone BJ, Wells CA, Berry AR, Ferguson JDP. Mammographic appearance and histopathological description of a muscular hamartoma of the breast. Br J Radiol. 1985; 58:459–461.

4. Helvie MA, Adler DD, Rebner M, Oberman HA. Breast hamartomas: variable mammographic appearance. Radiology. 1989; 170:417–421.

5. Wong KW, Ho WC, Wong TT. MRI of muscular hamartoma of the breast. Australas Radiol. 2002; 46:441–443.

6. Davies JD, Riddell RH. Muscular Hamartomas of the breast. J Pathol. 1973; 111:209–211.