J Korean Soc Radiol.  2010 Aug;63(2):189-192.

Myoid Hamartoma of the Breast: A Case Report

Affiliations
  • 1Department of Radiology, The Catholic University of Korea, Korea. lionmain@catholic.ac.kr
  • 2Department of Hospital Pathology, The Catholic University of Korea, Korea.

Abstract

Myoid (muscular) hamartoma is a rare subtype of hamartoma and is characterized by the presence of smooth muscle cells. We report a case of myoid hamartoma presenting as a large palpable mass in a 28-year-old patient, which was confirmed by surgical excision and pathologic diagnosis.


MeSH Terms

Adult
Breast Neoplasms
Hamartoma
Humans
Mammography
Myocytes, Smooth Muscle

Figure

  • Fig. 1 Mammography Findings. Craniocaudal (A), and mediolateral oblique (B) mammogram showed no remarkable mass shadow, except for a slightly bulging contour of the upper portion of the left breast on mediolateral oblique mammogram (white arrow).

  • Fig. 2 Ultrasonographic Findings. Longitudinal (A), transverse (B), and color Doppler (C) ultrasonogram revealed an isoechoic solid mass with focal inhomogeneously low echogenicity (white arrow). The mass had a lobulated shape, focal angular and microobulated margin (black arrows), as well as increased vascularity at the peripheral portion.

  • Fig. 3 Pathologic Findings. A. On H & E stain, the mass contained a smooth muscle cell bundle (black arrow) mixed with lobular structures (white arrow) and dilated ducts (asterisks) (H & E stain, ×20). B, C. Immunohistochemical staining of action (B), and heavy chain smooth muscle myosin (C) showed a strong positive finding (brown color).


Reference

1. Kang BS, Park JM. Muscular Hamartoma of the Breast: A Case Report. J Korean Radiol Soc. 2002; 47:99–101.
2. Stafyla V, Kotsifopoulos N, Grigoriadis K, Bokoyiannis CN, Peros G, Sakorafas GH. Myoid hamartoma of the breast : a case report and review of the literature. Breast J. 2007; 13:85–87.
3. Shepstone BJ, Wells CA, Berry AR, Ferguson JDP. Mammographic appearance and histopathological description of a muscular hamartoma of the breast. Br J Radiol. 1985; 58:459–461.
4. Helvie MA, Adler DD, Rebner M, Oberman HA. Breast hamartomas: variable mammographic appearance. Radiology. 1989; 170:417–421.
5. Wong KW, Ho WC, Wong TT. MRI of muscular hamartoma of the breast. Australas Radiol. 2002; 46:441–443.
6. Davies JD, Riddell RH. Muscular Hamartomas of the breast. J Pathol. 1973; 111:209–211.
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