J Breast Cancer.  2010 Mar;13(1):120-123. 10.4048/jbc.2010.13.1.120.

Myoid Hamartoma of the Breast with Synchronous Contralateral Breast Cancer: Report of a Case

• Cho JS
• Ryu HS
• Ro HW
• Lim HS
• Park MH
• Lee JS
• Yoon JH
• Jegal YJ

• KMID: 2286570
• DOI: http://doi.org/10.4048/jbc.2010.13.1.120

Abstract

Myoid hamartomas of the breast parenchyma are extremely rare, benign breast neoplasms. Only 15 cases of the parenchymal myoid hamartoma of the breast have currently been described in the medical literature written in English. A 46-year-old woman presented with a huge right breast myoid hamartoma and synchronous contralateral left periareolar cancer. We discuss the clinical features, the radiologic findings, the pathologic findings and the management of this type of lesion. Surgeons should be aware that myoid hamartoma is a rare benign tumor, but it can be the cause of a palpable mass in the breast.

Keyword

Breast neoplasms; Hamartoma; Synchronous neoplasms

MeSH Terms

Breast
Breast Neoplasms
Female
Hamartoma
Humans
Middle Aged
Neoplasms, Multiple Primary

Figure

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  Figure 1 Breast MRI shows a 9.2×7.2×7.1 cm mixed signal intensity lesion with variable enhancement in the right breast (R) and a 2.1×1.9×1.5 cm oval heterogeneously early enhancing mass in the periareolar area of the left breast.

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  Figure 2 The right breast mass is composed of intersecting bundles of spindle-shaped smooth muscle cells, and involves peripheral ducts and fat tissue (A, H&E stain, ×100). The spindle cells have eosinophilic cytoplasm and elongated cigar-shaped nuclei aggregated in small fascicles (B, H&E stain, ×400). Many spindle cells are strongly positive for actin (C, Immunohistochemical stain, ×100). Ductal epithelial cells and stromal spindle cells show nuclear positivity for PTEN (D, Immunohistochemical stain, ×100).

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