J Korean Soc Radiol.  2010 Aug;63(2):145-148.

Aggressive Pulmonary Inflammatory Myofibroblastic Tumor with Chest Wall Invasion: A Case Report

• Park SH
• Cho SG
• Yi HG
• Choi SJ
• Lee KH

Abstract

Inflammatory myofibroblastic tumor is a benign lesion in pathology. However it may be associated with the invasion of adjacent structures mimicking malignancy. We describe a case of aggressive pulmonary inflammatory myofibroblastic tumor with chest wall invasion and spine destruction.

MeSH Terms

Granuloma, Plasma Cell
Lung Diseases
Lung Neoplasms
Magnetic Resonance Imaging
Myofibroblasts
Spine
Thoracic Wall
Thorax
Tomography, X-Ray Computed

Figure

• 

  Fig. 1 Pulmonary inflammatory myofibroblastic tumor with bone destruction and spinal canal invasion in a 45-year-old man. A. Chest radiograph shows ill-defined increased opacity (arrow) in the left upper lobe above the aortic arch. B. Contrast-enhanced axial CT scan reveals a well-enhanced soft tissue mass (arrow) in the apicoposterior segment of the left upper lobe which extended to the chest wall with left 3 rd, and 4th rib destruction. The mass also invaded into the spinal canal with cord compression. C-E. Axial MR image shows a heterogeneous mass (arrow) with signal intensity slightly greater than that of the skeletal muscle on a T1-weighted image, slightly hyperintense on a T2-weighted image and moderately enhanced on a gadolinium-enhanced T1-weighted image. F. Microscopically, there is fascicular proliferation of plump spindle cells featuring myofibroblast (arrows) and inflammatory infiltrates mainly composed of plasma cells (arrow heads) (H & E, ×200). Inset shows myofibroblast with positive staining for smooth muscle actin. G. The marrow space of bone show extensive infiltration of mature plasma cells (arrow heads) along with loose myofibroblastic (arrows) proliferation.

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