Ann Dermatol.  2018 Oct;30(5):513-521. 10.5021/ad.2018.30.5.513.

Centennial History of Yonsei University Dermatology in Korea: 1917 to 2017

• Kim J
• Kim TG
• Lee SH
• Lee MK
• Kim JH
• Lee SE
• Kim DY
• Roh MR
• Park CO
• Lee JH
• Lee MG
• Bang D
• Oh SH
• Chung KY

• KMID: 2419739
• DOI: http://doi.org/10.5021/ad.2018.30.5.513

Abstract

Yonsei Dermatology celebrated its centennial in 2017, marking 100 years since Kung Sun Oh established the first Department of Dermatology and Urology in Korea in 1917. Following the footsteps of Kung Sun Oh, a pioneer of Korean dermatology, its members united and worked to provide the best medical service and achieve academic milestones in dermatology. Over the past hundred years, Yonsei Dermatology has played a pivotal role in the advancement of medical science and academia in Korea. The main activities of the department include medical care, education, and dermatologic research. Its research activities have encompassed a wide spectrum of dermatologic manifestations from skin immunology and pathology to introduction of newly developed treatment technologies. As Kung Sun Oh was the first Korean professor of dermatology at Severance Medical School and a passionate educator, we continue to serve his will by nurturing medical students and dermatology specialists to serve as global medical leaders. The Kung Sun Oh Memorial Lecture, first hosted in 1977, was the beginning of mutual international academic exchange in the field of dermatology in Korea. The memorial lecture has played a major role in advancing the academic status of Korean dermatological science by inviting distinguished dermatologists from around the world as guest lecturers. Yonsei Dermatology has played a key role in the history of modern medicine and dermatology in Korea over the last 100 years and continues to make an impact.

Keyword

Dermatology; Kung Sun Oh; Severance; Yonsei

MeSH Terms

Allergy and Immunology
Dermatology*
Education
History, Modern 1601-
Humans
Korea*
Pathology
Schools, Medical
Skin
Solar System
Specialization
Students, Medical
Urology

Figure

• 

  Fig. 1 (A) Kwanghyewon, renamed as Chejungwon (House of Civilized Virtue), at its opening as the Korea's first modernized hospital in 1885. (B) Present day Yonsei University Health System in 2017. (C) Lecture in Dermatology by Kung Sun Oh, the founder of Yonsei Dermatology, in 1931. The students were taught ‘Lupus Vulgaris’ as indicated in the blackboard. Adapted from Bang and Chung. Early Roots of Western Medicine and a Pioneer of Social Work in Korea: Dr. Kung Sun Oh (1878–1963). Yonsei Med J 2016;57:277–2826.

Reference

1. Yonsei University Medical School Dermatology. Yonsei university medical school dermatology 100 years. Seoul: Koonja;2017.

2. Roh MR, Lee KH, Lee S. HaeKwan Kung Sun Oh. In : Löser C, Plewig G, Burgdorf W, editors. Pantheon of Dermatology: outstanding historical figures. Heidelberg: Springer;2013. p. 816–820.

3. Park YK. Dermatology in Korea. Skinmed. 2007; 6:107–110. PMID: 17478987.

4. Parish LC, Woo TH. Kung Sun Oh: patriarch of Korean dermatology. Arch Dermatol. 1968; 98:406–407. PMID: 4877726.

5. Kee CD. Dr. Kung Sun Oh and the department of dermatology of Yonsei university college of medicine. Korean J Med Hist. 1996; 5:147–154.

6. Bang D, Chung KY. Early roots of western medicine and a pioneer of social work in Korea: Dr. Kung Sun Oh (1878-1963). Yonsei Med J. 2016; 57:277–282. PMID: 26847276.

7. Lee JB, Lee MG, Kim HI, Lee SN. 19S (IgM) - FTA test in untreated syphilitic patients. Korean J Dermatol. 1985; 23:630–634.

8. Lee JB, Farshy CE, Hunter EF, Hambie EA, Wobig GH, Larsen SA. Detection of immunoglobulin M in cerebrospinalfluid from syphilis patients by enzyme-linked-immunosorbent-assay. J Clin Microbiol. 1986; 24:736–740. PMID: 3533984.

9. Bang DS, Lee ES, Sohn SH, Kim DY, Cho SH, Choi MJ. Behçet's disease in Korea. Seoul: Hanuri;2013.

10. Sohn S, Lee ES, Bang D, Lee S. Behçet's disease-like symptoms induced by the herpes simplex virus in ICR mice. Eur J Dermatol. 1998; 8:21–23. PMID: 9649665.

11. Lee KH, Chung HS, Kim HS, Oh SH, Ha MK, Baik JH, et al. Human alpha-enolase from endothelial cells as a target antigen of anti-endothelial cell antibody in Behçet's disease. Arthritis Rheum. 2003; 48:2025–2035. PMID: 12847697.

12. Lee S, Bang D, Lee ES, Sohn S. Behçet's disease: a guide to its clinical understanding: textbook and atlas. Berlin: Springer;2001.

13. Hann SK, Im S, Bong HW, Park YK. Treatment of stable vitiligo with autologous epidermal grafting and PUVA. J Am Acad Dermatol. 1995; 32:943–948. PMID: 7751463.

14. Hann SK, Koo SW, Kim JB, Park YK. Detection of antibodies to human melanoma cells in vitiligo and alopecia areata by western blot analysis. J Dermatol. 1996; 23:100–103. PMID: 8839236.

15. Hann SK, Lee HJ. Segmental vitiligo: clinical findings in 208 patients. J Am Acad Dermatol. 1996; 35:671–674. PMID: 8912558.

16. Hann SK, Chang JH, Lee HS, Kim SM. The classification of segmental vitiligo on the face. Yonsei Med J. 2000; 41:209–212. PMID: 10817021.

17. Kim DY, Oh SH, Hann SK. Classification of segmental vitiligo on the face: clues for prognosis. Br J Dermatol. 2011; 164:1004–1009. PMID: 21198540.

18. Woo TH, Kook HI, Cho KY, Park YK. Clinical observation on the allergic contact dermatities in Korea. Korean J Dermatol. 1972; 10:77–83.

19. Bae JM, Choi YY, Park CO, Chung KY, Lee KH. Efficacy of allergen-specific immunotherapy for atopic dermatitis: a systematic review and meta-analysis of randomized controlled trials. J Allergy Clin Immunol. 2013; 132:110–117. PMID: 23647790.

20. Wu WH, Park CO, Oh SH, Kim HJ, Kwon YS, Bae BG, et al. Thymic stromal lymphopoietin-activated invariant natural killer T cells trigger an innate allergic immune response in atopic dermatitis. J Allergy Clin Immunol. 2010; 126:290–299. PMID: 20624642.

21. Noh S, Jin S, Park CO, Lee YS, Lee N, Lee J, et al. Elevated galectin-10 expression of IL-22-producing T cells in patients with atopic dermatitis. J Invest Dermatol. 2016; 136:328–331. PMID: 26763457.

22. Jin S, Shin JU, Noh JY, Kim H, Kim JY, Kim SH, et al. DOCK8: regulator of Treg in response to corticotropinreleasing hormone. Allergy. 2016; 71:811–819. PMID: 26799599.

23. Lew W, Bowcock AM, Krueger JG. Psoriasis vulgaris: cutaneous lymphoid tissue supports T-cell activation and "Type 1" inflammatory gene expression. Trends Immunol. 2004; 25:295–305. PMID: 15145319.

24. Kim TG, Jee H, Fuentes-Duculan J, Wu WH, Byamba D, Kim DS, et al. Dermal clusters of mature dendritic cells and T cells are associated with the CCL20/CCR6 chemokine system in chronic psoriasis. J Invest Dermatol. 2014; 134:1462–1465. PMID: 24401998.

25. Lee MG, Borkowski TA, Udey MC. Regulation of expression of B7 by murine Langerhans cells: a direct relationship between B7 mRNA levels and the level of surface expression of B7 by Langerhans cells. J Invest Dermatol. 1993; 101:883–886. PMID: 7504029.

26. Lee MG, Tang A, Sharrow SO, Udey MC. Murine dendritic T cells (DETC) express the homophilic adhesion molecule E-cadherin. Epithelial Cell Biol. 1994; 3:149–155. PMID: 7550606.

27. Park JM, Je JH, Wu WH, Jee HJ, Lee SK, Lee MG. Attenuation of contact hypersensitivity by cell-permeable heat shock protein 70 in BALB/c mouse model. Exp Dermatol. 2012; 21:969–971. PMID: 23171464.

28. Lee SH, Elias PM, Proksch E, Menon GK, Mao-Quiang M, Feingold KR. Calcium and potassium are important regulators of barrier homeostasis in murine epidermis. J Clin Invest. 1992; 89:530–538. PMID: 1737844.

29. Ahn BK, Jeong SK, Kim HS, Choi KJ, Seo JT, Choi EH, et al. Rottlerin, a specific inhibitor of protein kinase C-delta, impedes barrier repair response by increasing intracellular free calcium. J Invest Dermatol. 2006; 126:1348–1355. PMID: 16575394.

30. Lee SH, Choi EH, Feingold KR, Jiang S, Ahn SK. Iontophoresis itself on hairless mouse skin induces the loss of the epidermal calcium gradient without skin barrier impairment. J Invest Dermatol. 1998; 111:39–43. PMID: 9665384.

31. Jeong SK, Kim HJ, Youm JK, Ahn SK, Choi EH, Sohn MH, et al. Mite and cockroach allergens activate protease-activated receptor 2 and delay epidermal permeability barrier recovery. J Invest Dermatol. 2008; 128:1930–1939. PMID: 18305573.

32. Kim SC, Kwon YD, Lee IJ, Chang SN, Lee TG. cDNA cloning of the 210-kDa paraneoplastic pemphigus antigen reveals that envoplakin is a component of the antigen complex. J Invest Dermatol. 1997; 109:365–369. PMID: 9284106.

33. Kim TH, Choi Y, Lee SE, Lim JM, Kim SC. Adjuvant rituximab treatment for pemphigus: a retrospective study of 45 patients at a single center with long-term follow up. J Dermatol. 2017; 44:615–620. PMID: 28186358.

34. Oh SW, Lee JS, Kim MY, Kim SC. COL7A1 mutational analysis in Korean patients with dystrophic epidermolysis bullosa. Br J Dermatol. 2007; 157:1260–1264. PMID: 17916216.

35. Gu LH, Kim SC, Ichiki Y, Park J, Nagai M, Kitajima Y. A usual frameshift and delayed termination codon mutation in keratin 5 causes a novel type of epidermolysis bullosa simplex with migratory circinate erythema. J Invest Dermatol. 2003; 121:482–485. PMID: 12925204.

36. Kim DS, Kim DH, Goo B, Cho YH, Park JM, Lee TH, et al. Immunotherapy of malignant melanoma with tumor lysatepulsed autologous monocyte-derived dendritic cells. Yonsei Med J. 2011; 52:990–998. PMID: 22028165.

37. Oh BH, Jang HS, Lee J, Choi MJ, Nam KA, Chung KY. Delayed reconstruction for the non-amputative treatment of subungual melanoma. Ann Dermatol. 2015; 27:417–422. PMID: 26273158.

38. Lee KY, Roh MR, Chung WG, Chung KY. Comparison of Mohs micrographic surgery and wide excision for extramammary Paget's disease: Korean experience. Dermatol Surg. 2009; 35:34–40. PMID: 19018812.

39. Nasemann T. The Kung-Sun-Oh memorial lecture and impressions on dermatology during a trip to South Korea. Hautarzt. 1978; 29:395–397. PMID: 681179.