Radiat Oncol J.  2018 Mar;36(1):25-34. 10.3857/roj.2017.00409.

Initial clinical outcomes of proton beam radiotherapy for hepatocellular carcinoma

• Yu JI
• Yoo GS
• Cho S
• Jung SH
• Han Y
• Park S
• Lee B
• Kang W
• Sinn DH
• Paik YH
• Gwak GY
• Choi MS
• Lee JH
• Koh KC
• Paik SW
• Park HC

• KMID: 2418882
• DOI: http://doi.org/10.3857/roj.2017.00409

Abstract

PURPOSE
This study aimed to evaluate the initial outcomes of proton beam therapy (PBT) for hepatocellular carcinoma (HCC) in terms of tumor response and safety.
MATERIALS AND METHODS
HCC patients who were not indicated for standard curative local modalities and who were treated with PBT at Samsung Medical Center from January 2016 to February 2017 were enrolled. Toxicity was scored using the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. Tumor response was evaluated using modified Response Evaluation Criteria in Solid Tumors (mRECIST).
RESULTS
A total of 101 HCC patients treated with PBT were included. Patients were treated with an equivalent dose of 62-92 GyE10. Liver function status was not significantly affected after PBT. Greater than 80% of patients had Child-Pugh class A and albumin-bilirubin (ALBI) grade 1 up to 3-months after PBT. Of 78 patients followed for three months after PBT, infield complete and partial responses were achieved in 54 (69.2%) and 14 (17.9%) patients, respectively.
CONCLUSION
PBT treatment of HCC patients showed a favorable infield complete response rate of 69.2% with acceptable acute toxicity. An additional follow-up study of these patients will be conducted.

Keyword

Hepatocellular carcinoma; Proton; Radiotherapy; Response; Toxicity

MeSH Terms

Carcinoma, Hepatocellular*
Follow-Up Studies
Humans
Liver
Proton Therapy
Protons*
Radiotherapy*
Response Evaluation Criteria in Solid Tumors
Protons