Radiat Oncol J.
2018 Jun;36(2):153-162. 10.3857/roj.2017.00542.
Clinical outcomes and prognostic factors in patients with mycosis fungoides who underwent radiation therapy in a single institution
- Affiliations
-
- 1Department of Radiation Oncology, Seoul National University Hospital, Seoul, Korea. ihkim@snu.ac.kr
- 2Institute of Radiation Medicine, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
- 3Program in Biomedical Radiation Sciences, Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.
- KMID: 2418876
- DOI: http://doi.org/10.3857/roj.2017.00542
Abstract
- PURPOSE
We aimed to evaluate clinical outcomes including progression-free survival (PFS), overall survival (OS), partial response, and complete response in patients who underwent radiation therapy (RT) for mycosis fungoides (MF). Also, we sought to find prognostic factors for clinical outcomes.
MATERIALS AND METHODS
Total 19 patients confirmed with MF between 1999-2015 were retrospectively reviewed. Clinical and treatment characteristics, clinical outcomes, and and toxicities were analyzed.
RESULTS
Eleven patients were treated with total skin electron beam radiotherapy (TSEBT) and 8 patients with involved field radiation therapy (IFRT) with median dose of 30 Gy, respectively. The median time interval from diagnosis to RT was 2.6 months (range, 0.4 to 87.3 months). The overall response rate was 100%; 11 patients (57.9%) had a complete response and 8 patients (42.1%) a partial response. The presence of positive lymph node at the time of consultation of RT was associated with lower OS (p = 0.043). In multivariate analysis, PFS was significantly lower for patients with increased previous therapies experienced following RT (p = 0.019) and for patients showing PR during RT (p = 0.044). There were no reported grade 3 or more skin toxicities related with RT.
CONCLUSION
Both IFRT and TSEBT are effective treatment for MF patients. Patients with short disease course before RT or complete response during RT are expected to have longer PFS. Positive lymph node status at the initiation of RT was associated woth poor OS, suggesting other treatment modalities such as low-dose RT for patients with low life-expectancy.
