Cancer Res Treat.  2018 Jul;50(3):950-955. 10.4143/crt.2017.357.

Utility of the National Lung Screening Trial Criteria for Estimation of Lung Cancer in the Korean Population

• Lee YJ
• Choi SM
• Lee J
• Lee CH
• Lee SM
• Yoo CG
• Kim YW
• Han SK
• Park YS

• KMID: 2417883
• DOI: http://doi.org/10.4143/crt.2017.357

Abstract

PURPOSE
Screening forlung cancerin high-risk patients using the National Lung Screening Trial (NLST) criteria resulted in a decreased lung cancer-related mortality rate. However, whether these criteria are applicable to the Korean has not been investigated thus far. Therefore, we estimated the utility of the NLST criteria as a screening tool for lung cancer in the Korean population.
MATERIALS AND METHODS
The total number of newly diagnosed lung cancer cases in 2013 was obtained from the Korea National Statistical Office. The proportion of newly diagnosed lung cancer cases that met the NLST criteria was calculated via a retrospective cohort of a tertiary referral hospital. We estimated the nationwide proportion of patients who met the NLST criteria using the 5th Korea National Health and Nutrition Examination Survey conducted during 2010-2012 (KNHANES V).
RESULTS
Using KNHANES V data, we found that approximately 6.92% of the general population of Korea would meet the NLST criteria. In the tertiary referral hospital, 29.6% of the 2,689 newly diagnosed lung cancer patients met the NLST criteria. In 2013, the total number of newly diagnosed lung cancer cases in Korea was 23,177. The estimated nationwide proportions of lung cancer patients who met and did not meet the NLST criteria were 0.37% and 0.06%, respectively, yielding a ratio of 5.78.
CONCLUSION
The NLST criteria demonstrated sound clinical utility for lung cancer screening of high-risk patients in Korea.

Keyword

Lung neoplasms; Screening; Korea

MeSH Terms

Cohort Studies
Humans
Korea
Lung Neoplasms*
Lung*
Mass Screening*
Mortality
Nutrition Surveys
Retrospective Studies
Tertiary Care Centers

Figure

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  Fig. 1. (A) Flow diagram of study population (fifth Korea National Health and Nutrition Examination Survey [KNHANES V]). (B) Flow diagram of study population (Seoul National University Hospital [SNUH]). NLST, National Lung Screening Trial.

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  Fig. 2. Estimation of lung cancer incidence in Koreans ≥ 40 years using National Lung Screening Trial (NLST) criteria. SNUH, Seoul National University Hospital; KNHANES V, fifth Korea National Health and Nutrition Examination Survey.

Reference

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