Ann Pediatr Endocrinol Metab.  2018 Jun;23(2):75-80. 10.6065/apem.2018.23.2.75.

Etiological trends in male central precocious puberty

• Lee J
• Kim J
• Yang A
• Cho SY
• Jin DK

• KMID: 2417763
• DOI: http://doi.org/10.6065/apem.2018.23.2.75

Abstract

PURPOSE
In the present study, the etiological trends in male central precocious puberty (CPP) were examined, and annual distribution was evaluated.
METHODS
Seventy-one male CPP subjects who started puberty before 9 years of age were included in this study. All individuals were diagnosed as having CPP at Samsung Medical Center between 2001 and 2016. Chronological age at puberty onset, diagnosis of CPP, bone age, weight (kg), height (cm), puberty stage, brain magnetic resonance imaging findings, testosterone level, basal gonadotropin level, and gonadotropin level after gonadotropin releasing hormone stimulation were analyzed.
RESULTS
The 71 patients were divided into 2 groups: idiopathic (group I) and organic (group II) when the lesion was identified as associated with the central nervous system (CNS) or when the patient received chemotherapy for non-CNS tumors before CPP diagnosis, respectively. Forty-four cases (62%) were idiopathic, and 27 (38%) were organic. The proportion of idiopathic CPP was higher than that of organic CPP during the study period. In 51.9% of organic cases, puberty started before 8 years of age, whereas it started after that age in 93.2% of the idiopathic cases.
CONCLUSIONS
In the present study, among all male CPP cases, 62% were idiopathic. The probability of idiopathic CPP prevalence was higher in males when the puberty onset was after 8 years of age with no history of cranial radiotherapy or chemotherapy.

Keyword

Precocious puberty; Male; Brain magnetic resonance imaging; Radiotherapy

MeSH Terms

Adolescent
Brain
Central Nervous System
Diagnosis
Drug Therapy
Gonadotropin-Releasing Hormone
Gonadotropins
Humans
Magnetic Resonance Imaging
Male*
Prevalence
Puberty
Puberty, Precocious*
Radiotherapy
Testosterone
Gonadotropin-Releasing Hormone
Gonadotropins
Testosterone

Figure

• 

  Fig. 1. The cases were divided into 4 groups according to the following referral periods: 2001–2004, 2005–2008, 2009–2012, and 2013–2016. It showed that the number of male central precocious puberty (CPP) cases increased over the years. Idiopathic CPP was identified as the main proportion for this increase.

Reference

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