J Gynecol Oncol.  2018 Jul;29(4):e54. 10.3802/jgo.2018.29.e54.

Is the ovarian preservation safe in young women with stages IB–IIA villoglandular adenocarcinoma of the uterine cervix?

• Ju UC
• Kang WD
• Kim SM

• KMID: 2417443
• DOI: http://doi.org/10.3802/jgo.2018.29.e54

Abstract

OBJECTIVE
Because villoglandular adenocarcinoma (VGA) of the uterine cervix has favorable features and outcomes, patients receive less radical surgery and young women preserve their ovaries. We aimed to evaluate the clinicopathological features and outcomes of VGA and to see if the ovarian preservation is safe in young women with VGA.
METHODS
We retrospectively reviewed medical records and identified patients with VGA, who had been treated and followed from January 2004 to December 2015.
RESULTS
This study consisted of 17 patients with VGA, including 9 premenopausal women. International Federation of Gynecology and Obstetrics (FIGO) stage IB1 disease was found in 12 patients (70.6%), IA1 in 2, IA2 in 1, IB2 in 1, and IIA1 in 1. Of the 12 women diagnosed with stage IB1 disease, a young woman received only conization and she has not showed a recurrence. During a median follow-up of 58 months (range: 12-116), 4 patients, who had undergone radical surgery for stage IB1 disease, had a recurrence and one of them died due to disease progression. Among patients with stages IB-IIA disease, 2 premenopausal women did not receive simultaneous oophorectomy or chemoradiation therapy. Both of them had a recurrent tumor at adnexa.
CONCLUSION
This study revealed favorable features and outcomes of VGA. However, the appropriate treatment for young women with early-stage VGA must be cautiously selected. Ovarian preservation might not be safe when young women with stages IB-IIA VGA undergo surgical procedures.

Keyword

Adenocarcinoma, Papillary; Uterine Cervical Neoplasms; Therapy; Fertility Preservation; Treatment Outcome

MeSH Terms

Adenocarcinoma*
Adenocarcinoma, Papillary
Cervix Uteri*
Conization
Disease Progression
Female
Fertility Preservation
Follow-Up Studies
Gynecology
Humans
Medical Records
Obstetrics
Ovariectomy
Ovary
Recurrence
Retrospective Studies
Treatment Outcome
Uterine Cervical Neoplasms