J Korean Neurosurg Soc.  2018 Jul;61(4):525-529. 10.3340/jkns.2018.0002.

Fractionated Stereotactic Radiosurgery for Brain Metastases Using the Novalis Tx® System

Affiliations
  • 1Department of Neurosurgery, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.

Abstract


OBJECTIVE
To evaluate the efficacy of fractionated stereotactic radiosurgery (FSRS) performed using the Novalis Tx® system (BrainLAB AG, Feldkirchen, Germany; Varian Medical Systems, Palo Alto, CA, USA) for brain metastases.
METHODS
Between March 2013 and July 2016, 23 brain metastases patients were admitted at a single institute. Twenty-nine lesions too large for single session stereotactic radiosurgery or located in the vicinity of eloquent structures were treated by FSRS. Based on the results obtained, we reviewed the efficacy and toxicity of FSRS for the treatment of brain metastases.
RESULTS
The most common lesion origin was lung (55%) followed by breast (21%). Median overall survival was 10.0 months (95% confidence interval [CI], 4.9-15.0), and median progression-free survival was 10.0 months (95% CI, 2.1-13.9). Overall survival rates at 1 and 2 years were 58.6% and 36.0%, respectively. Local recurrence and neurological complications affecting morbidity each occurred in two cases.
CONCLUSION
FSRS using the Novalis-Tx® system would appear to be an effective, safe noninvasive treatment modality for large and eloquently situated brain metastases. Further investigation is required on a larger number of patients.

Keyword

Stereotactic radiosurgery; Brain tumor; Radiosurgery; Metastasis

MeSH Terms

Brain Neoplasms
Brain*
Breast
Disease-Free Survival
Germany
Humans
Lung
Neoplasm Metastasis*
Radiosurgery*
Recurrence
Survival Rate

Figure

  • Fig. 1. Overall and progression free survivals of patients that underwent FSRS for brain metastases. FSRS : fractionated stereotactic radiosurgery.


Cited by  1 articles

Two-Day Fraction Gamma Knife Radiosurgery for Large Brain Metastasis
Joo-Hwan Lee, In-Young Kim, Shin Jung, Tae-Young Jung, Kyung-Sub Moon, Yeong-Jin Kim, Sue-Jee Park, Sa-Hoe Lim
J Korean Neurosurg Soc. 2024;67(5):560-567.    doi: 10.3340/jkns.2023.0214.


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