Ann Geriatr Med Res.  2017 Jun;21(2):70-77. 10.4235/agmr.2017.21.2.70.

Weight Status and All-Cause Mortality in Older Adults: A Study of Patients With Type 2 Diabetes Undergoing Subtotal Gastrectomy for Cancer

• Kwon Y
• Kim KJ
• Roh YK
• Park YG
• Park S
• Cho KH

• KMID: 2415659
• DOI: http://doi.org/10.4235/agmr.2017.21.2.70

Abstract

BACKGROUND
The survival benefit of excess body weight is controversial across various subpopulations. We assessed the effect of weight status on all-cause mortality among patients with type 2 diabetes (T2DM) undergoing subtotal gastrectomy for gastric cancer.
METHODS
Medical charts of 210 patients with T2DM treated at 2 university hospitals were examined retrospectively. All patients had undergone subtotal gastrectomy for cancer between January 1993 and December 2012. Participants were categorized as normal weight (body mass index [BMI], 18.5-24.99 kg/m²) or overweight/obese (BMI≥25 kg/m²). The association between weight status and all-cause mortality was assessed using weighted Cox proportional hazard regression models and inverse probability weighting.
RESULTS
The mortality rate was 25.2% after a median follow-up duration of 6.1 years (interquartile range, 3.5-8.3 years; maximum, 14.4 years). The overweight/obese group had a significantly lower risk of all-cause mortality (hazard ratio, 0.51; 95% confidence interval, 0.34-0.77; p=0.001) compared with the normal weight group. Overweight/obesity was associated with reduced all-cause mortality in patients aged <65 years (p=0.01 for interaction).
CONCLUSION
Among T2DM patients who underwent subtotal gastrectomy for cancer, only the subgroup of patients aged <65 years in the overweight/obese group showed reduced all-cause mortality compared with the normal weight group.

Keyword

Type 2 diabetes; Body mass index; Subtotal gastrectomy; Stomach neoplasms; Mortality

MeSH Terms

Adult*
Body Mass Index
Body Weight
Follow-Up Studies
Gastrectomy*
Hospitals, University
Humans
Mortality*
Retrospective Studies
Stomach Neoplasms