J Clin Neurol.  2018 Jul;14(3):420-422. 10.3988/jcn.2018.14.3.420.

Alanyl-tRNA Synthetase 2-Related Dementia with Selective Bilateral Frontal Cystic Leukoencephalopathy

• Carle G
• Morin A
• Noiray C
• Roy-Joly P
• Cohen L
• Levy R
• Samaan S
• Nadjar Y

• KMID: 2415064
• DOI: http://doi.org/10.3988/jcn.2018.14.3.420

Abstract

No abstract available.

MeSH Terms

Alanine-tRNA Ligase*
Dementia*
Leukoencephalopathies*
Alanine-tRNA Ligase

Figure

• 

  Fig. 1 Brain magnetic resonance imaging changes in our patient. A: Axial T1-weighted sequence. B: Sagittal T1-weighted sequence. C: Axial FLAIR T2-weighted sequence. D: Sagittal FLAIR T2-weighted sequence. Confluent white-matter abnormalities are restricted to the frontal lobes with high T2-weighted FLAIR signals (arrows in C) and low T1-weighted signals, centered by a very low T1-weighted signal, corresponding to a cyst (arrows in A). Frontal lobes are atrophic, with enlargement of the contiguous part of the lateral ventricles. The corpus callosum genu is highly atrophic with a high T2-weighted FLAIR signal. Mild atrophy of the cerebellum is also noted. FLAIR: fluid-attenuated inversion recovery.

Reference

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