J Korean Neurol Assoc.
2014 Aug;32(3):168-170.
Reversible Cerebellar Leukoencephalopathy Associated With Oral Methotrexate
- Affiliations
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- 1Department of Neurology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea. aelee@cnu.ac.kr
Abstract
- Methotrexate (MTX)-induced leukoencephalopathy is the most often reported leukoencephalopathy following intrathecal or intravenous administration. A 72-year-old woman developed leukoencephalopathy localized to the cerebellum after treatment with oral MTX at a dose of 15 mg/week for 3 years. She complained of subtle imbalance during walking and reported having fallen. Her symptoms improved after discontinuation of MTX, and the leukoencephalopathy resolved. This is therefore a case report of selective cerebellar reversible leukoencephalopathy associated with oral MTX.
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