Nucl Med Mol Imaging.  2018 Jun;52(3):238-242. 10.1007/s13139-018-0520-2.

Incidental Detection of Parathyroid Adenoma on Somatostatin Receptor PET/CT and Incremental Role of ¹⁸F-Fluorocholine PET/CT in MEN1 Syndrome

• Arora S
• Damle NA
• Passah A
• Yadav MP
• Ballal S
• Aggarwal V
• Gupta Y
• Kumar P
• Tripathi M
• Bal C

• KMID: 2414816
• DOI: http://doi.org/10.1007/s13139-018-0520-2

Abstract

Multiple endocrine neoplasia type 1 (MEN1) syndrome is characterized by combined occurrence of tumors of endocrine glands including the parathyroid, the pancreatic islet cells, and the anterior pituitary gland. Parathyroid involvement is the most common manifestation and usually the first clinical involvement inMEN1 syndrome, followed by gastroentero-pancreatic neuroendocrine tumors (NETs). Here we present a case where the patient initially presented with metastatic gastric NET and a single parathyroid adenoma was detected incidentally on ⁶⁸Ga-DOTANOC PET/CT done as part of post ¹â·â·Lu-DOTATATE therapy (PRRT) follow-up. Further ¹â¸F-fluorocholine PET/CT showed four adenomas for which the patient subsequently underwent subtotal parathyroidectomy.

Keyword

¹⁸F-Fluorocholine PET/CT; MEN1; Gastrinoma; Hyperparathyroidism; ¹⁷⁷Lu-DOTATATE therapy

MeSH Terms

Adenoma
Endocrine Glands
Follow-Up Studies
Gastrinoma
Humans
Hyperparathyroidism
Islets of Langerhans
Multiple Endocrine Neoplasia Type 1*
Neuroendocrine Tumors
Parathyroid Neoplasms*
Parathyroidectomy
Pituitary Gland, Anterior
Positron-Emission Tomography and Computed Tomography*
Receptors, Somatostatin*
Somatostatin*
Receptors, Somatostatin
Somatostatin