Korean J Gastroenterol.  2018 Jun;71(6):338-348. 10.4166/kjg.2018.71.6.338.

Gastrointestinal cancer risk in patients with a family history of gastrointestinal cancer

• Chung JW
• Park JJ
• Lim YJ
• Lee J
• Kim SM
• Han JH
• Jeon SR
• Lee HS
• Kim YS
• Song SY
• Committee of Education and Ethics of the Korean Society of Gastrointestinal Cancer

• KMID: 2414460
• DOI: http://doi.org/10.4166/kjg.2018.71.6.338

Abstract

BACKGROUND/AIMS
This study was performed to evaluate the relationship between family history of gastrointestinal (GI) cancers and incidence of any GI cancer in the Korean population.
METHODS
Between January 2015 and July 2016, 711 GI cancer patients and 849 controls in 16 hospitals in Korea were enrolled. Personal medical histories, life styles, and family history of GI cancers were collected via questionnaire.
RESULTS
There was a significant difference in the incidence of family history of GI cancer between GI cancer patients and controls (p=0.002). Patients with family history of GI cancer tended to be diagnosed as GI cancer at younger age than those without family history (p=0.016). The family members of GI cancer patients who were diagnosed before 50 years of age were more frequently diagnosed as GI cancer before the age of 50 years (p=0.017). After adjusting for major confounding factors, age (adjusted odds ratio [AOR] 1.065, 95% confidence interval [CI]; 1.053-1.076), male gender (AOR 2.270, 95% CI; 1.618-3.184), smoking (AOR 1.570, 95% CI; 1.130-2.182), and sibling's history of GI cancer (AOR 1.973, 95% CI; 1.246-3.126) remained independently associated with GI cancers.
CONCLUSIONS
GI cancer patients tended to have a first relative with a history of concordant GI cancer. Personal factors (old age and male) and lifestyle (smoking) contribute to the development of GI cancer, independently. Individuals with high risk for GI cancers may be advised to undergo screening at an earlier age.

Keyword

Gastrointestinal neoplasm; Medical history taking; Risk factors

MeSH Terms

Age Factors
Gastrointestinal Neoplasms*
Humans
Incidence
Korea
Life Style
Male
Mass Screening
Medical History Taking
Odds Ratio
Risk Factors
Smoke
Smoking
Smoke

Reference

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