J Vet Sci.  2016 Dec;17(4):577-582. 10.4142/jvs.2016.17.4.577.

Effects of gonadotropin-releasing hormone administration or a controlled internal drug-releasing insert after timed artificial insemination on pregnancy rates of dairy cows

• Jeong JK
• Choi IS
• Kang HG
• Hur TY
• Kim IH

• KMID: 2412615
• DOI: http://doi.org/10.4142/jvs.2016.17.4.577

Abstract

This study investigated the effects of gonadotrophin-releasing hormone (GnRH) administration (Experiment 1) and a controlled internal drug-releasing (CIDR) insert (Experiment 2) after timed artificial insemination (TAI) on the pregnancy rates of dairy cows. In Experiment 1, 569 dairy cows that underwent TAI (day 0) following short-term synchronization with prostaglandin F(2α) were randomly allocated into two groups: no further treatment (control, n = 307) or injection of 100 µg of gonadorelin on day 5 (GnRH, n = 262). In Experiment 2, 279 dairy cows that underwent TAI (day 0) following Ovsynch were randomly allocated into two groups: no further treatment (control, n = 140) or CIDR insert treatment from days 3.5 to 18 (CIDR, n = 139). The probability of pregnancy following TAI did not differ between the GnRH (34.4%) and control (31.6%, p > 0.05) groups. However, the probability of pregnancy following TAI was higher (odds ratio: 1.74, p < 0.05) in the CIDR group (51.1%) than in the control group (39.3%). Overall, CIDR insert treatment at days 3.5 to 18 increased pregnancy rates relative to non-treated controls, whereas a single GnRH administration on day 5 did not affect the pregnancy outcomes of dairy cows.

Keyword

dairy cow; post-insemination; pregnancy rate; progesterone concentration

MeSH Terms

Animals
Cattle/*physiology
Cloprostenol/*pharmacology
Contraceptive Agents/administration & dosage
Estradiol/administration & dosage/analogs & derivatives
Female
Gonadotropin-Releasing Hormone/*pharmacology
Insemination, Artificial/veterinary
Luteolytic Agents/*pharmacology
Pregnancy
*Pregnancy Rate
Reproduction/drug effects
Contraceptive Agents
Luteolytic Agents
Gonadotropin-Releasing Hormone
Cloprostenol
Estradiol

Figure

• 

  Fig. 1 A diagram of the experimental design for the timed artificial insemination (TAI) regimens, and treatment with gonadotrophin-releasing hormone (GnRH) (Experiment 1) or a controlled internal drug-releasing (CIDR) insert (Experiment 2) post-insemination. PG, 500 µg of cloprostenol; EB, 1 mg of estradiol benzoate; Ultras, ultrasonography to examine corpus luteum(s); GnRH, 100 µg of gonadorelin; Preg Diag, pregnancy diagnosis using ultrasonography; CIDR, CIDR insert containing 1.9 g of progesterone.

• 

  Fig. 2 Serum progesterone concentrations in CIDR-treated cows and non-treated controls at 3.5, 5, and 13 days after TAI in Experiment 2. Group, treatment group effect; Day, sampling period effect; Group*Day, group-by-sampling period effect.

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