J Vet Sci.  2017 Jun;18(2):169-173. 10.4142/jvs.2017.18.2.169.

Tissue distribution of marbofloxacin in pigs after a single intramuscular injection

• Yang F
• Liu Y
• Li Z
• Wang Y
• Liu B
• Zhao Z
• Zhou B
• Wang G

• KMID: 2412569
• DOI: http://doi.org/10.4142/jvs.2017.18.2.169

Abstract

Tissue distribution of marbofloxacin was studied in pigs after a single intramuscular injection at 2.5 mg/kg body weight. Samples of plasma, muscle, liver, kidney, heart, lung, and muscle at the injection site were randomly collected from five pigs at 2, 6, 10, 24, 48, 72, and 96 h after administration. Marbofloxacin concentrations were determined by using high-performance liquid chromatography with ultraviolet detection and were subjected to non-compartmental analysis to obtain kinetic parameters. The elimination half-life (t(1/2λz)) of marbofloxacin at the injection site was 22.12 h, while those in kidney, plasma, liver, lung, heart, and muscle were 16.75, 21.48, 21.84, 24.00, 24.45, and 28.91 h, respectively. Areas under the concentration-time curve from 0 h to (∞) (AUC(0-∞)s) were calculated to be 31.17 h·µg·mL⁻¹ for plasma and 32.97, 33.92, 34.78, 37.58, 42.02, and 98.80 h·µg·g⁻¹ for heart, muscle, lung, liver, kidney, and injection site, respectively. The peak concentration (C(max)) of marbofloxacin was 1.62 µg/mL in plasma and 1.71, 1.74, 1.86, 1.93, 2.45, and 7.64 µg/g in heart, lung, muscle, kidney, liver, and injection site, respectively. The results show that marbofloxacin was fast absorbed, extensively distributed, and slowly eliminated from pigs after a single intramuscular administration.

Keyword

kinetic parameters; marbofloxacin; pigs; tissue distribution

MeSH Terms

Animals
Anti-Bacterial Agents/administration & dosage/analysis/*pharmacokinetics
Chromatography, High Pressure Liquid/veterinary
Fluoroquinolones/administration & dosage/analysis/*pharmacokinetics
Injections, Intramuscular/veterinary
Kidney/chemistry
Liver/chemistry
Lung/chemistry
Male
Muscle, Skeletal/chemistry
Myocardium/chemistry
Swine/metabolism
Anti-Bacterial Agents
Fluoroquinolones

Figure

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  Fig. 1 Concentrations of marbofloxacin in kidney, lung, and heart after a single intramuscular injection (2.5 mg/kg body weight) in pigs.

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  Fig. 2 Concentrations of marbofloxacin in liver and at injection site after a single intramuscular injection (2.5 mg/kg body weight) in pigs.

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  Fig. 3 Concentrations of marbofloxacin in muscle and plasma after a single intramuscular injection (2.5 mg/kg body weight) in pigs.

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