J Vet Sci.  2018 May;19(3):472-476. 10.4142/jvs.2018.19.3.472.

Double filtration plasmapheresis in the treatment of hyperproteinemia in dogs affected by Leishmania infantum

• Perondi F
• Brovida C
• Ceccherini G
• Guidi G
• Lippi I

• KMID: 2412139
• DOI: http://doi.org/10.4142/jvs.2018.19.3.472

Abstract

Three dogs were evaluated for severe hyperproteinemia and hyperglobulinemia secondary to Leishmania infantum. Double filtration plasmapheresis (DFPP) was performed in two dogs at days 1, 2, and 6 after presentation. The third dog received DFPP at days 1 and 3 after presentation and eleven hemodialysis treatments. Significant reduction in serum total protein (p < 0.0001), alpha-1 (p = 0.023), alpha-2 (p = 0.018), gamma globulins (p = 0.0105), and a significant increase in albumin/globulin ratio (p = 0.0018) were found. DFPP may be a promising therapeutic technique for rapid resolution of signs of hyperproteinemia in dogs affected by L. infantum.

Keyword

Leishmania infantum; dogs; double filtration plasmapheresis; hyperproteinemia

MeSH Terms

Animals
Dogs*
Filtration*
gamma-Globulins
Leishmania infantum*
Leishmania*
Plasmapheresis*
Renal Dialysis
gamma-Globulins

Figure

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  Fig. 1 A Diapact CRRT machine (B Braun Avitum) continuous renal replacement therapy machine was used as the plasmapheresis modality.

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