Gut Liver.  2016 Sep;10(5):731-738. 10.5009/gnl15323.

Prognosis of Pregnancy-Associated Gastric Cancer: An Age-, Sex-, and Stage-Matched Case-Control Study

• Song MJ
• Park YS
• Song HJ
• Park SJ
• Ahn JY
• Choi KD
• Lee GH
• Jung HY
• Yook JH
• Kim BS

• KMID: 2412070
• DOI: http://doi.org/10.5009/gnl15323

Abstract

BACKGROUND/AIMS
Pregnancy-associated gastric cancer is a rare condition. This case-control study was performed to identify the clinicopathological features and prognostic factors of pregnancy-associated gastric cancer.
METHODS
All consecutive patients who presented to our tertiary referral hospital with pregnancy-associated gastric cancer from 1991 to 2012 were identified. Two age-, sex-, and stage-matched controls for each case were also identified from the records. Clinicopathological, gynecological, and oncological outcomes were recorded. Immunohistochemical staining was performed for estrogen receptor, progesterone receptor, epidermal growth factor receptor, human epidermal growth factor receptor, and E-cadherin. Fluorescence in situ hybridization was performed for fibroblast growth factor receptor 2.
RESULTS
The median overall survival rates of the pregnancy-associated gastric cancer and control groups were 7.0 months and 15.0 months, respectively (p=0.189). Poor prognostic factors included advanced stage and tumor location in the corpus or the entire stomach but not pregnancy status or loss of E-cadherin. Pregnancy-associated gastric cancer was associated with a longer time from diagnosis to treatment (21 days vs 7 days, p=0.021). The two groups did not differ in the expression of the receptors or E-cadherin.
CONCLUSIONS
The dismal prognosis of pregnancy-associated gastric cancer may related to the tumor stage and location rather than to pregnancy itself.

Keyword

Gastric neoplasms; Pregnancy; Prognosis; E-cadherins

MeSH Terms

Adult
Biomarkers, Tumor/analysis
Cadherins/analysis
Case-Control Studies
ErbB Receptors/analysis
Female
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Neoplasm Staging
Pregnancy
Pregnancy Complications, Neoplastic/*mortality/pathology
Prognosis
Receptor, Fibroblast Growth Factor, Type 2/analysis
Receptors, Estrogen/analysis
Receptors, Progesterone/analysis
Stomach/pathology
Stomach Neoplasms/chemistry/*mortality/pathology
Survival Rate
Time-to-Treatment
Young Adult
Biomarkers, Tumor
Cadherins
Receptors, Estrogen
Receptors, Progesterone
ErbB Receptors
Receptor, Fibroblast Growth Factor, Type 2