Cancer Res Treat.  2018 Apr;50(2):374-381. 10.4143/crt.2017.119.

Interstitial Lung Disease and Lung Cancer Development: A 5-Year Nationwide Population-Based Study

• Choi WI
• Park SH
• Park BJ
• Lee CW

• KMID: 2411127
• DOI: http://doi.org/10.4143/crt.2017.119

Abstract

PURPOSE
In this nationwide 5-year longitudinal population-based study, we aimed at investigating the incidence of lung cancer among patients with interstitial lung disease.
MATERIALS AND METHODS
Data was collected from the Korean National Health Insurance Research Database from 49,773,195 Korean residents in 2009. Thirteen thousand six hundred and sixty-six patients with interstitial lung disease diagnosed January-December 2009. The end of follow-up was June 30, 2014. Up to four matching chronic obstructive pulmonary disease controls were selected to compare the lung cancer high-risk group based on age, sex, diagnosis date (within 30 days), and hospital size. The number of patients with newly developed lung cancer was determined.
RESULTS
The incidences of lung cancer were 126.98, 156.62, and 370.38 cases per 10,000 person-years (2,732, 809, and 967 cases of cancer, respectively) in the chronic obstructive pulmonary disease, interstitial lung disease, and chronic obstructive pulmonary disease with interstitial lung disease groups, respectively. Of the 879 patients with idiopathic pulmonary fibrosis, 112 developed lung cancer (incidence, 381.00 cases per 10,000 person-years).
CONCLUSION
Incidence of lung cancer among patients with interstitial lung disease was high. Interstitial lung diseases have a high potential for developing into lung cancer, even when concurrent with chronic obstructive pulmonary disease.

Keyword

Incidence; Interstitial lung diseases; Longitudinal studies; Lung neoplasms; Chronic obstructive pulmonary disease

MeSH Terms

Diagnosis
Follow-Up Studies
Health Facility Size
Humans
Idiopathic Pulmonary Fibrosis
Incidence
Longitudinal Studies
Lung Diseases, Interstitial*
Lung Neoplasms*
Lung*
National Health Programs
Pulmonary Disease, Chronic Obstructive

Figure

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  Fig. 1. Flow chart of the study. Patient selection flow chart for interstitial lung disease (ILD) (A) and chronic obstructive pulmonary disease (COPD) (B). ICD-10, International Classification of Disease, 10th revision.

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  Fig. 2. Cumulative incidence curve of lung cancer by Kaplan-Meier analysis. General population (blue line), ILD (red line), COPD (green line), IPF (orange line), and COPD with ILD (gray line). ILD, interstitial lung disease; COPD, chronic obstructive pulmonary disease; IPF, idiopathic pulmonary fibrosis.

Reference

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