Kidney Res Clin Pract.  2017 Mar;36(1):95-99. 10.23876/j.krcp.2017.36.1.95.

HELLP syndrome in a pregnant patient with Gitelman syndrome

• Lee M
• Kim DI
• Lee KH
• Byun JH
• Hwang J
• Hwang WM
• Yun SR
• Yoon SH

• KMID: 2409394
• DOI: http://doi.org/10.23876/j.krcp.2017.36.1.95

Abstract

Gitelman syndrome is characterized by hypokalemia, metabolic alkalosis, hypocalciuria, and hypomagnesemia. The clinical course of Gitelman syndrome in pregnant women remains unclear, but it is thought to be benign. We report here the first Korean case of atypical eclampsia in a 31-year-old who was diagnosed with Gitelman syndrome incidentally during an antenatal screening test. The patient did well during pregnancy despite significant hypokalemia. At 33 weeks' gestation, the patient exhibited eclampsia, hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome, and renal insufficiency without significant hypertension or proteinuria. We explain this unusual clinical course through a review of the relevant literature.

Keyword

Eclampsia; Gitelman syndrome; HELLP syndrome; Pregnancy

MeSH Terms

Adult
Alkalosis
Eclampsia
Female
Gitelman Syndrome*
HELLP Syndrome*
Hemolysis
Humans
Hypertension
Hypokalemia
Liver
Pregnancy
Pregnant Women
Prenatal Diagnosis
Proteinuria
Renal Insufficiency