Infect Chemother.  2018 Mar;50(1):43-47. 10.3947/ic.2018.50.1.43.

Outcome in Patients with Fever of Unknown Origin whose ¹⁸Fluoro-Deoxyglucose Positron Emission Tomography/Computerized Tomography Finding is Non-Diagnostic

Affiliations
  • 1Division of Infectious Diseases, Soonchunhyang University Bucheon Hospital, Bucheon, Korea. mdchoo@schmc.ac.kr
  • 2Division of Rheumatology, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
  • 3Department of Nuclear Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.

Abstract

Prognosis has not been known for patients with fever of unknown origin (FUO) whose ¹â¸fluoro-deoxyglucose (¹â¸F-FDG) positron emission tomography/computerized tomography (PET/CT) finding is non-diagnostic. A total of eight patients with FUO that underwent ¹â¸F-FDG PET/CT were retrospectively identified January 2016 - June 2017 in a tertiary hospital in Korea. Of these, two patients were diagnosed with microscopic polyangitis and Kikuchi's disease and one patient was transferred to another hospital. Of five patients whose diagnoses were not confirmed, four patients received non-steroidal anti-inflammatory drug and/or low dose steroid and symptoms disappeared. Our study suggests that outcome of patients with FUO whose ¹â¸F-FDG PET/CT finding is non-diagnostic would be favorable.

Keyword

¹⁸fluoro-deoxyglucose; Positron emission tomography/computerized tomography; Fever of unknown origin; Prognosis

MeSH Terms

Diagnosis
Electrons*
Fever of Unknown Origin*
Fever*
Histiocytic Necrotizing Lymphadenitis
Humans
Korea
Positron-Emission Tomography and Computed Tomography
Prognosis
Retrospective Studies
Tertiary Care Centers

Reference

1. Bharucha T, Rutherford A, Skeoch S, Alavi A, Brown M, Galloway J. FDG-PET/CT in fever of unknown origin working group. Diagnostic yield of FDG-PET/CT in fever of unknown origin: a systematic review, meta-analysis, and Delphi exercise. Clin Radiol. 2017; 72:764–771.
Article
2. Besson FL, Chaumet-Riffaud P, Playe M, Noel N, Lambotte O, Goujard C, Prigent A, Durand E. Contribution of (18)F-FDG PET in the diagnostic assessment of fever of unknown origin (FUO): a stratification-based meta-analysis. Eur J Nucl Med Mol Imaging. 2016; 43:1887–1895.
Article
3. Sioka C, Assimakopoulos A, Fotopoulos A. The diagnostic role of (18)F fluorodeoxyglucose positron emission tomography in patients with fever of unknown origin. Eur J Clin Invest. 2015; 45:601–608.
Article
4. Schonau V, Vogel K, Englbrecht M, Wacker J, Schmidt D, Manger B, Kuwert T, Schett G. The value of 18F-FDG-PET/CT in identifying the cause of fever of unknown origin (FUO) and inflammation of unknown origin (IUO): data from a prospective study. Ann Rheum Dis. 2018; 77:70–77.
Article
5. Durack DT, Street AC. Fever of unknown origin--reexamined and redefined. Curr Clin Top Infect Dis. 1991; 11:35–51.
6. Mourad O, Palda V, Detsky AS. A comprehensive evidence-based approach to fever of unknown origin. Arch Intern Med. 2003; 163:545–551.
Article
7. Knockaert DC, Dujardin KS, Bobbaers HJ. Long-term follow-up of patients with undiagnosed fever of unknown origin. Arch Intern Med. 1996; 156:618–620.
Article
8. Hung BT, Wang PW, Su YJ, Huang WC, Chang YH, Huang SH, Chang CC. The efficacy of 18F-FDG PET/CT and 67Ga SPECT/CT in diagnosing fever of unknown origin. Int J Infect Dis. 2017; 62:10–17.
Article
9. Revest M, Patrat-Delon S, Devillers A, Tattevin P, Michelet C. Contribution of 18fluoro-deoxyglucose PET/CT for the diagnosis of infectious diseases. Med Mal Infect. 2014; 44:251–260.
Article
10. Kim J, Oh MD. FDG PET-CT in the diagnosis of Takayasu arteritis rresenting as fever of unknown origin: a case report. Infect Chemother. 2015; 47:190–193.
Article
11. Pereira AM, Husmann L, Sah BR, Battegay E, Franzen D. Determinants of diagnostic performance of 18F-FDG PET/CT in patients with fever of unknown origin. Nucl Med Commun. 2016; 37:57–65.
Article
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