Nucl Med Mol Imaging.  2018 Feb;52(1):74-79. 10.1007/s13139-017-0471-z.

Systemic Lupus Erythematosus Associated Pitfalls on ¹⁸F-FDG PET/CT: Reactive Follicular Hyperplasia, Kikuchi-Fujimoto Disease, Inflammation and Lymphoid Hyperplasia of the Spleen Mimicking Lymphoma

• Makis W
• Ciarallo A
• Milene GV
• Probst S

• KMID: 2407305
• DOI: http://doi.org/10.1007/s13139-017-0471-z

Abstract

Systemic lupus erythematosus (SLE) is associated with a variety of inflammatory processes that can affect the lymph nodes, brain, kidneys, and spleen. We present two patients with SLE in whom SLE-associated conditions complicated interpretation of ¹â¸F-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) imaging of the lymph nodes and the spleen. The imaging findings mimicked lymphoma, but histopathological evaluation showed benign processes including reactive follicular hyperplasia in the lymph nodes, Kikuchi-Fujimoto disease in perisplenic lymph nodes, and inflammatory changes and lymphoid hyperplasia in the spleen.

Keyword

Systemic lupus erythematosus; SLE; Lymphoma; Kikuchi-Fujimoto disease; Spleen; PET/CT

MeSH Terms

Brain
Electrons
Histiocytic Necrotizing Lymphadenitis*
Humans
Hyperplasia*
Inflammation*
Kidney
Lupus Erythematosus, Systemic*
Lymph Nodes
Lymphoma*
Positron-Emission Tomography and Computed Tomography*
Spleen*