Infect Chemother.  2010 Apr;42(2):117-121.

Two Cases of Respiratory Distress Syndrome Caused by Hospital-Acquired Pandemic Influenza (H1N1 2009) in Kidney Transplant Recipients

• Kim JH
• Kwon SH
• Lee EJ
• Kim EJ
• Kim TH
• Jeon JS
• Noh H
• Han DC

Abstract

Since pandemic influenza was declared by WHO at June 2009, severe pandemic influenza cases were reported among pregnant, obese, immunocompromised patients including transplant candidates and recipients were reported. Here we report two cases of pandemic influenza (H1N1 2009) with respiratory distress syndrome in adult patients with kidney transplantation. They were successfully treated with combination of antiviral therapy including high dose oseltamivir. Although clinical symptoms and signs were improved immediately when anti-viral therapy was started, radiologic finding resolved after several weeks.

Keyword

Pandemic influenza/Respiratory distress syndrome; Adult/Kidney transplantation

MeSH Terms

Adult
Humans
Immunocompromised Host
Influenza, Human
Kidney
Kidney Transplantation
Oseltamivir
Pandemics
Transplants
Oseltamivir

Figure

• 

  Figure 1 This figure shows the clinical course of the case 1. On day 5 of admission, high body temperature, worsening hypoxia, and dyspnea developed. He was given invasive ventilator care in ICU. Clinical symptoms and signs improved immediately when anti-viral therapy started. ICU, intensive care unit; GW. General ward.

• 

  Figure 2 This figure shows the clinical course of the case 2. She was transferred to the ICU because clinical condition deteriorated on day 6 of admission. On day 11 of admission, worsening hypoxia developed, the use of mechanical ventilator care required. Although BK amputation was done, her clinical status continued to deteriorated, with persistent fever and hypoxia. Pandemic influenza (H1N1 2009) was identified by real time PCR from nasal swab on operation day. Clinical symptoms and signs were resolved when anti-viral therapy was started. ICU, intensive care unit; GW. General ward; BK, below-knee.

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