J Korean Neurol Assoc.
2017 Nov;35(4):211-214. 10.17340/jkna.2017.4.5.
Co-occurrence of Guillain-Barré Syndrome and Acute Disseminated Encephalomyelitis with Dual Positive of Anti-GT1a and Anti-GM1 Antibodies
- Affiliations
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- 1Department of Neurology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. jongseokbae@hallym.or.kr
- 2Department of Neurology, Dong-A University Hospital, Dong-A University College of Medicine, Busan, Korea.
- KMID: 2405980
- DOI: http://doi.org/10.17340/jkna.2017.4.5
Abstract
- Acute disseminated encephalomyelitis (ADEM) and Guillain-Barré syndrome (GBS) are both rare post-infectious neurological disorders. The co-existence of these conditions has often been reported despite of low incidence. We describe a 20-year-old male, who presented with acute flaccid paralysis and encephalopathy. The patient showed reversible MRI lesions suggesting ADEM. This case showed anti-GT1a IgG and anti-GM1 IgM antibodies positivity. We suggest that certain immunogenicity within central and peripheral nervous system may share a common autoimmune process during the disease course.
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