J Korean Neurol Assoc.  2017 Nov;35(4):199-202. 10.17340/jkna.2017.4.2.

Reversible Cause of Rapidly Progressive Dementia as Presenting Symptom of Primary Hyperparathyroidism

Affiliations
  • 1Department of Neurology, Korea University Medical Center, Seoul, Korea. sodium75@hanmail.net

Abstract

Primary hyperparathyroidism (PHPT) is imbalance of calcium, phosphate, and bone metabolism attributed to an increased secretion of parathyroid hormone (PTH). Although PHPT is mainly associated with musculoskeletal and kidney dysfunction, variable symptoms can be presented in the elderly patients. A 75-year-old man presented with rapidly progressive dementia (RPD). Through etiological work-up of hypercalcemia and increased PTH, parathyroid adenoma was found. Subtotal parathyroidectomy resulted in recovery of cognitive impairment. Primary hyperparathyroidism should be considered in a differential diagnosis of RPD.

Keyword

Hyperparathyroidism; Hypercalcemia; Dementia

MeSH Terms

Aged
Calcium
Cognition Disorders
Dementia*
Diagnosis, Differential
Humans
Hypercalcemia
Hyperparathyroidism
Hyperparathyroidism, Primary*
Kidney
Metabolism
Parathyroid Hormone
Parathyroid Neoplasms
Parathyroidectomy
Calcium
Parathyroid Hormone
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